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Plea for an international Aneurysm Data Bank: description and perspectives
- Source :
- Neurosurgical Focus, Vol. 47, No 1 (2019) P. E17
- Publication Year :
- 2019
- Publisher :
- Journal of Neurosurgery Publishing Group (JNSPG), 2019.
-
Abstract
- The disease resulting in the formation, growth, and rupture of intracranial aneurysms is complex. Research is accumulating evidence that the disease is driven by many different factors, some constant and others variable over time. Combinations of factors may induce specific biophysical reactions at different stages of the disease. A better understanding of the biophysical mechanisms responsible for the disease initiation and progression is essential to predict the natural history of the disease. More accurate predictions are mandatory to adequately balance risks between observation and intervention at the individual level as expected in the age of personalized medicine. Multidisciplinary exploration of the disease also opens an avenue to the discovery of possible preventive actions or medical treatments. Modern information technologies and data processing methods offer tools to address such complex challenges requiring 1) the collection of a high volume of information provided globally, 2) integration and harmonization of the information, and 3) management of data sharing with a broad spectrum of stakeholders.Over the last decade an infrastructure has been set up and is now made available to the academic community to support and promote exploration of intracranial disease, modeling, and clinical management simulation and monitoring.The background and purpose of the infrastructure is reviewed. The infrastructure data flow architecture is presented. The basic concepts of disease modeling that oriented the design of the core information model are explained. Disease phases, milestones, cases stratification group in each phase, key relevant factors, and outcomes are defined. Data processing and disease model visualization tools are presented. Most relevant contributions to the literature resulting from the exploitation of the infrastructure are reviewed, and future perspectives are discussed.
- Subjects :
- Databases, Factual
Computer science
International Cooperation
Data management
0206 medical engineering
005: Computerprogrammierung, Programme und Daten
02 engineering and technology
Disease
ddc:616.07
computer.software_genre
616: Innere Medizin und Krankheiten
03 medical and health sciences
0302 clinical medicine
Multidisciplinary approach
Database, factual
Humans
Computer Simulation
Information Dissemination
business.industry
Information technology
Intracranial Aneurysm
General Medicine
020601 biomedical engineering
ddc:616.8
Data sharing
Disease modeling
Risk analysis (engineering)
Information model
Epidemiological Monitoring
Data integration
Surgery
Neurology (clinical)
Personalized medicine
business
computer
030217 neurology & neurosurgery
Human
Subjects
Details
- ISSN :
- 10920684
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- Neurosurgical Focus
- Accession number :
- edsair.doi.dedup.....d1d589de861a9939b1a641077da63edd