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ΔNp63α controls YB-1 protein stability: Evidence on YB-1 as a new player in keratinocyte differentiation
- Publication Year :
- 2016
-
Abstract
- Y-box binding protein 1 (YBX-1 or YB-1) is an oncoprotein that promotes replicative immortality, tumor cell invasion and metastasis. The increase in the abundance of YB-1 in the cell or YB-1 translocation from the cytoplasm to the nucleus is characteristic of malignant cell growth. We have previously reported that ΔNp63α, a transcription factor that is known to play a pivotal role in keratinocyte proliferation and differentiation, promotes YB-1 nuclear accumulation. Here, we show that YB-1 is highly expressed in proliferating keratinocytes and is down-regulated during keratinocyte differentiation. ΔNp63α reduces YB-1 protein turnover and leads to accumulation of ubiquitin-conjugated YB-1 into the nucleus. Reduction of YB-1 protein level, following treatment with a DNA-damaging agent, is inhibited by ΔNp63α suggesting that YB-1 and ΔNp63α interplay can support keratinocyte proliferation and protect cells from apoptosis under genotoxic stress.
- Subjects :
- Keratinocytes
0301 basic medicine
Cellular differentiation
Cell
Down-Regulation
Biology
Cell Line
03 medical and health sciences
Cell Line, Tumor
Genetics
medicine
Humans
Transcription factor
Tumor
Protein Stability
Tumor Suppressor Proteins
Binding protein
Cell Cycle
Cell Differentiation
Cell Biology
Cell cycle
Y box binding protein 1
Cell biology
030104 developmental biology
medicine.anatomical_structure
Transcription Factors
Y-Box-Binding Protein 1
Cytoplasm
Genetics, Cell Biology, keratinocyte proliferation and differentiation
Keratinocyte
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....d1c6d9c7e01a47cd1776664e83eb4f90