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Celecoxib Versus Placebo in Tonsillectomy
- Source :
- Annals of Otology, Rhinology & Laryngology. 125:785-800
- Publication Year :
- 2016
- Publisher :
- SAGE Publications, 2016.
-
Abstract
- Objectives: Celecoxib is a cyclooxygenase-2-specific inhibitor indicated to treat acute pain and pain secondary to osteoarthritis and rheumatoid arthritis. Surgical models of acute pain have demonstrated superior pain relief to placebo. The objective of this study was to test the safety and efficacy of celecoxib for pain relief after tonsillectomy compared to placebo. Methods: Adult subjects were randomized to 200 mg celecoxib versus placebo with a loading dose the night before surgery then twice daily for 10 days. Subjects were instructed to supplement the study drug with hydrocodone/acetaminophen liquid or acetaminophen for pain as needed. Subjects completed a daily diary regarding their pain, nausea, vomiting, diet, and activity. Results: Seventeen subjects enrolled. Intraoperative blood loss was similar between groups, and no subject had postoperative bleeding. Three patients returned to the emergency department for treatment, and 2 patients could not complete the diaries, all in the placebo group. Subjects in the placebo group required statistically significant ( P < .05) higher doses of narcotic and acetaminophen to control pain. Pain and diet rating scores were slightly better in the celecoxib group compared to placebo. Conclusions: In this small cohort, celecoxib reduced postoperative narcotic and acetaminophen requirements compared to placebo without complications.
- Subjects :
- Adult
Male
medicine.medical_treatment
Placebo-controlled study
Osteoarthritis
Placebo
Young Adult
03 medical and health sciences
0302 clinical medicine
Double-Blind Method
Recurrence
medicine
Humans
Pain Management
Hydrocodone
Prospective Studies
030223 otorhinolaryngology
Acetaminophen
Pain Measurement
Tonsillectomy
Pain, Postoperative
Cyclooxygenase 2 Inhibitors
business.industry
General Medicine
Analgesics, Non-Narcotic
medicine.disease
Analgesics, Opioid
Drug Combinations
Tonsillitis
Otorhinolaryngology
Celecoxib
030220 oncology & carcinogenesis
Anesthesia
Rheumatoid arthritis
Chronic Disease
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 1943572X and 00034894
- Volume :
- 125
- Database :
- OpenAIRE
- Journal :
- Annals of Otology, Rhinology & Laryngology
- Accession number :
- edsair.doi.dedup.....d1c3e7122995c1f86b57b01b1404b323