Back to Search
Start Over
Radioprotection of Lung Tissue by Soy Isoflavones
- Source :
- Journal of Thoracic Oncology. 8:1356-1364
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- Introduction: Radiation-induced pneumonitis and fibrosis have restricted radiotherapy for lung cancer. In a preclinical lung tumor model, soy isoflavones showed the potential to enhance radiation damage in tumor nodules and simultaneously protect normal lung from radiation injury. We have further dissected the role of soy iso- flavones in the radioprotection of lung tissue. Methods: Naive Balb/c mice were treated with oral soy isoflavones for 3 days before and up to 4 months after radiation. Radiation was administered to the left lung at 12 Gy. Mice were monitored for toxic- ity and breathing rates at 2, 3, and 4 months after radiation. Lung tis- sues were processed for histology for in situ evaluation of response. Results: Radiation caused damage to normal hair follicles, leading to hair loss in the irradiated left thoracic area. Supplementation with soy isoflavones protected mice against radiation-induced skin injury and hair loss. Lung irradiation also caused an increase in mouse breathing rate that was more pronounced by 4 months after radia- tion, probably because of the late effects of radiation-induced injury to normal lung tissue. However, this effect was mitigated by soy isoflavones. Histological examination of irradiated lungs revealed a chronic inflammatory infiltration involving alveoli and bronchioles and a progressive increase in fibrosis. These adverse effects of radia- tion were alleviated by soy isoflavones. Conclusion: Soy isoflavones given pre- and postradiation protected the lungs against adverse effects of radiation including skin injury, hair loss, increased breathing rates, inflammation, pneumonitis and fibrosis, providing evidence for a radioprotective effect of soy.
- Subjects :
- Pulmonary and Respiratory Medicine
Pathology
medicine.medical_specialty
Pulmonary Fibrosis
medicine.medical_treatment
Radiation-Protective Agents
Article
Mice
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Fibrosis
Pulmonary fibrosis
Animals
Medicine
Lung cancer
Lung
Skin
030304 developmental biology
Pneumonitis
Mice, Inbred BALB C
Photons
0303 health sciences
Radiation
Protection
business.industry
Alopecia
Dose-Response Relationship, Radiation
respiratory system
Isoflavones
medicine.disease
3. Good health
Radiation Pneumonitis
Soy
Radiation therapy
Hair loss
medicine.anatomical_structure
Oncology
chemistry
030220 oncology & carcinogenesis
Dietary Supplements
Respiratory Mechanics
Female
Soybeans
business
Subjects
Details
- ISSN :
- 15560864
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Journal of Thoracic Oncology
- Accession number :
- edsair.doi.dedup.....d1c0da766fbdb890814f68f19bc4b43f