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Image overlay solution based on threshold detection for a compact near infrared fluorescence goggle system
- Publication Year :
- 2015
- Publisher :
- Society of Photo-Optical Instrumentation Engineers, 2015.
-
Abstract
- Near infrared (NIR) fluorescence imaging has shown great potential for various clinical procedures, including intraoperative image guidance. However, existing NIR fluorescence imaging systems either have a large footprint or are handheld, which limits their usage in intraoperative applications. We present a compact NIR fluorescence imaging system (NFIS) with an image overlay solution based on threshold detection, which can be easily integrated with a goggle display system for intraoperative guidance. The proposed NFIS achieves compactness, light weight, hands-free operation, high-precision superimposition, and a real-time frame rate. In addition, the miniature and ultra-lightweight light-emitting diode tracking pod is easy to incorporate with NIR fluorescence imaging. Based on experimental evaluation, the proposed NFIS solution has a lower detection limit of 25 nM of indocyanine green at 27 fps and realizes a highly precise image overlay of NIR and visible images of mice in vivo. The overlay error is limited within a 2-mm scale at a 65-cm working distance, which is highly reliable for clinical study and surgical use.
- Subjects :
- Indocyanine Green
Fluorescence-lifetime imaging microscopy
Computer science
Research Papers: Imaging
Biomedical Engineering
ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION
Overlay
Image (mathematics)
law.invention
Biomaterials
Optics
law
Image Processing, Computer-Assisted
Superimposition
Animals
Mice, Inbred BALB C
Spectroscopy, Near-Infrared
business.industry
Near-infrared spectroscopy
Optical Imaging
Equipment Design
Frame rate
Atomic and Molecular Physics, and Optics
Electronic, Optical and Magnetic Materials
Image-guided surgery
Eyeglasses
Semiconductors
Surgery, Computer-Assisted
business
Algorithms
Light-emitting diode
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....d1b26ffb4a907c5b6afd6c22f038810d