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Mechanotransduction and Cytoskeleton Remodeling Shaping YAP1 in Gastric Tumorigenesis
- Source :
- International Journal of Molecular Sciences, International Journal of Molecular Sciences, Vol 20, Iss 7, p 1576 (2019)
- Publication Year :
- 2019
- Publisher :
- MDPI, 2019.
-
Abstract
- The essential role of Hippo signaling pathway in cancer development has been elucidated by recent studies. In the gastrointestinal tissues, deregulation of the Hippo pathway is one of the most important driving events for tumorigenesis. It is widely known that Yes-associated protein 1 (YAP1) and WW domain that contain transcription regulator 1 (TAZ), two transcriptional co-activators with a PDZ-binding motif, function as critical effectors negatively regulated by the Hippo pathway. Previous studies indicate the involvement of YAP1/TAZ in mechanotransduction by crosstalking with the extracellular matrix (ECM) and the F-actin cytoskeleton associated signaling network. In gastric cancer (GC), YAP1/TAZ functions as an oncogene and transcriptionally promotes tumor formation by cooperating with TEAD transcription factors. Apart from the classic role of Hippo-YAP1 cascade, in this review, we summarize the current investigations to highlight the prominent role of YAP1/TAZ as a mechanical sensor and responder under mechanical stress and address its potential prognostic and therapeutic value in GC.
- Subjects :
- Carcinogenesis
Hippo pathway
YAP1
Review
medicine.disease_cause
Mechanotransduction, Cellular
Models, Biological
Catalysis
Inorganic Chemistry
Extracellular matrix
WW domain
lcsh:Chemistry
F-actin
Stomach Neoplasms
medicine
Animals
Humans
Physical and Theoretical Chemistry
Mechanotransduction
Molecular Biology
Transcription factor
lcsh:QH301-705.5
Spectroscopy
Cytoskeleton
Adaptor Proteins, Signal Transducing
Hippo signaling pathway
Oncogene
biology
gastric cancer
Organic Chemistry
mechanical strain
General Medicine
Computer Science Applications
Cell biology
lcsh:Biology (General)
lcsh:QD1-999
biology.protein
Subjects
Details
- Language :
- English
- ISSN :
- 14220067
- Volume :
- 20
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....d1ad5f18f92cf8b5932a1b8708cc2952