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The effects of treatment regimen on the initial management of macular neovascularization subtypes in age-related macular degeneration
- Source :
- Ophthalmologica, Ophthalmologica, 2023, ⟨10.1159/000529409⟩
- Publication Year :
- 2023
- Publisher :
- HAL CCSD, 2023.
-
Abstract
- OBJECTIVE: To evaluate the effect of initial treatment regimen individualization, (Pro Re nata (PRN) or Treat-and-Extend (TAE)), according to macular neovascularization (MNV) subtype, on the functional and anatomical response in neovascular age-related macular degeneration (nAMD). The secondary objective is to compare the treatment burden between each MNV subtypes. METHODS: Consecutive treatment-naïve nAMD patients were retrospectively included. MNV subtype was graded by 2 independent blinded investigators on multimodal imaging. Functional and anatomical outcomes were analysed according to treatment regimen and MNV subtypes. RESULTS: A total of 281 eyes from 243 patients were included in the study. According to the treatment regimen, there was no significant difference in best-corrected visual acuity gain within the 2 first year of treatment for type 1 (p=0.106) and type 3 MNV (p=0.704). Conversely, there was a significant difference in favour of TAE regimen for type 2 (p=0.017) and type 4 MNV (p=0.047). Type 1 MNV had a higher proportion of visits with subretinal fluid (p=0.0007), but not with intraretinal fluid (p=0.22). The mean interval between the last 2 injections was significantly shorter for type 1 MNV (p=0.0045). CONCLUSION: The individualization of the initial treatment protocol according to MNV subtype can improve the functional outcome and may decrease the treatment burden.
- Subjects :
- [PHYS]Physics [physics]
Ophthalmology
General Medicine
Sensory Systems
Subjects
Details
- Language :
- English
- ISSN :
- 00303755 and 14230267
- Database :
- OpenAIRE
- Journal :
- Ophthalmologica, Ophthalmologica, 2023, ⟨10.1159/000529409⟩
- Accession number :
- edsair.doi.dedup.....d1a916bb7b62a4bef449c3068af9e3b9