Electrical stimulation of midbrain raphe: Biochemical, behavioral and bioelectrical effects

Electrical stimulation of MR in rats induces a marked increase of 5HIAA and a decrease of 5HT in the forebrain. At the same time the onset of electroencephalographic pattern of sleep and behavioral signs of calmness were observed. The most intense biochemical effects were obtained with 10 c/sec stimulation whereas 2 c/sec stimulation produced the clearest behavioral depression. 5HT Midbrain raphe 5HIAA Electroencephalographic changes Behavior Sleep pattern Electrical stimulation