Back to Search
Start Over
Epigenetic Regulation of Mitochondrial Quality Control Genes in Multiple Myeloma: A Sequenom MassARRAY Pilot Investigation on HMCLs
- Source :
- Journal of Clinical Medicine, Vol 10, Iss 1295, p 1295 (2021), Journal of Clinical Medicine
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- The mitochondrial quality control network includes several epigenetically-regulated genes involved in mitochondrial dynamics, mitophagy, and mitochondrial biogenesis under physiologic conditions. Dysregulated expression of such genes has been reported in various disease contexts, including cancer. However, their expression pattern and the possible underlying epigenetic modifications remain to be defined within plasma cell (PC) dyscrasias. Herein, we compared the mRNA expression of mitochondrial quality control genes from multiple myeloma, plasma cell leukemia patients and human myeloma cell lines (HMCLs) with healthy plasma cells; moreover, by applying the Sequenom MassARRAY EpiTYPER technology, we performed a pilot investigation of their CpG methylation status in HMCLs. Overall, the results provided indicate dysregulated expression of several mitochondrial network’s genes, and alteration of the CpG methylation profile, underscoring novel potential myeloma biomarkers deserving in-depth functional investigation in the future.
- Subjects :
- Plasma cell leukemia
0303 health sciences
business.industry
Communication
lcsh:R
lcsh:Medicine
General Medicine
Methylation
medicine.disease
cancer epigenetics
Sequenom MassARRAY
03 medical and health sciences
0302 clinical medicine
Mitochondrial biogenesis
030220 oncology & carcinogenesis
DNA methylation
Mitophagy
Cancer research
Medicine
Cancer epigenetics
Epigenetics
methylation
business
Multiple myeloma
030304 developmental biology
Subjects
Details
- Language :
- English
- ISSN :
- 20770383
- Volume :
- 10
- Issue :
- 1295
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Medicine
- Accession number :
- edsair.doi.dedup.....d190f327133ad0c324cfaf8bded5409f