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Subchronic effects of cadmium on the gonads, expressions of steroid hormones and sex-related genes in tilapia Oreochromis niloticus
- Source :
- Ecotoxicology. 24:2213-2223
- Publication Year :
- 2015
- Publisher :
- Springer Science and Business Media LLC, 2015.
-
Abstract
- Cadmium (Cd) is one of the most toxic heavy metals in aquatic ecosystem which affects fish health and aquaculture. In the present study, we examined the bioaccumulation of Cd in the gonads of tilapia via dissolved and dietary routes. We evaluated the subchronic effects of Cd on the histology of gonads, steroid hormone levels and sex-related gene expressions in tilapia. In addition, we also studied maternal transfer of Cd. Our results indicated that Cd was accumulated significantly in both ovary and testis from both exposure routes. Histopathological analysis showed that Cd induced ovary and testis injuries. Estradiol levels were significantly increased in dissolved Cd exposed female fish. In addition, the Cd exposure displayed different effects on gene expressions in gonads. In females, the estrogen receptor (ERα) was stimulated in dissolved Cd-exposed fish at 70.32 and 143.78 μg/L for 30 days and in fish at 143.78 μg/L for 60 days. Vitellogenin expression was significantly down-regulated in the ovary of dissolved Cd-exposed fish. In testis, GR expression was elevated after 60 days of dissolved Cd and dietary exposure. Furthermore, Cd level was significantly higher in the eggs than that in the fry. Our results demonstrated that both dissolved and dietary Cd exposures affected gonad development by altering steroid hormone levels and sex-related gene expressions in tilapia.
- Subjects :
- Male
medicine.medical_specialty
food.ingredient
Gonad
Health, Toxicology and Mutagenesis
medicine.medical_treatment
Gene Expression
Ovary
Management, Monitoring, Policy and Law
Toxicology
Random Allocation
Vitellogenin
Nile tilapia
food
Internal medicine
Testis
medicine
Animals
Gonadal Steroid Hormones
Dose-Response Relationship, Drug
biology
Toxicity Tests, Subchronic
Tilapia
Cichlids
General Medicine
biology.organism_classification
Steroid hormone
Oreochromis
medicine.anatomical_structure
Endocrinology
biology.protein
Female
Development of the gonads
Water Pollutants, Chemical
Cadmium
Subjects
Details
- ISSN :
- 15733017 and 09639292
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Ecotoxicology
- Accession number :
- edsair.doi.dedup.....d189e9d46268084852651b9c5cb06e1e