Supplementary Figure 6 from Characterization of a New Class of Androgen Receptor Antagonists with Potential Therapeutic Application in Advanced Prostate Cancer

PDF file, 1976K, (A) Inhibition of in vitro polymerization of tubulin at 37 {degree sign}C by various concentrations of VPC-3033; turbidity was recorded at 360 nM.The steady-state tubulin assembly level in the absence of inhibitor was set at 100%. (B) IC50 values were determined by sigmoidal fitting of the plot of the steady state levels of tubulin assembly (taken after 45 min) aginst drug concentration and represent the concentration for 50% inhibition of the maximum tubulin polymerization level.