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E. coli strain engineering for the production of advanced biopharmaceutical products
- Source :
- FEMS Microbiology Letters. 365
- Publication Year :
- 2018
- Publisher :
- Oxford University Press (OUP), 2018.
-
Abstract
- Since the emergence of the biopharmaceutical industry in the 1980's, Escherichia coli, has played an important role in the industrial production of recombinant proteins and plasmid DNA for therapeutic use. Currently, advanced biopharmaceutical products, including rationally designed recombinant proteins and viral-vector gene therapies, offer unprecedented promise for the long-term management, and even cure of disease. As such, E. coli remains an important production host for the biopharmaceutical industry. This review provides insight into the industrially relevant strain engineering approaches used to enhance both the quantity and quality of these therapeutic products.
- Subjects :
- 0301 basic medicine
medicine.disease_cause
Microbiology
Recombinant Proteins
Metabolic engineering
03 medical and health sciences
030104 developmental biology
Biopharmaceutical
Biopharmaceutical industry
Metabolic Engineering
Plasmid dna
Escherichia coli
Genetics
medicine
Business
Biochemical engineering
Molecular Biology
Subjects
Details
- ISSN :
- 15746968
- Volume :
- 365
- Database :
- OpenAIRE
- Journal :
- FEMS Microbiology Letters
- Accession number :
- edsair.doi.dedup.....d176a9a7b9b0578e78a9b39b361f773f