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Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease: Observational and Mendelian Randomization Analyses
- Source :
- Circulation, 146(20), 1507-1517. Lippincott Williams & Wilkins, Emerging Risk Factors Collaboration/EPIC-CVD/Million Veteran Program 2022, ' Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease : Observational and Mendelian Randomization Analyses ', Circulation, vol. 146, no. 20, pp. 1507-1517 . https://doi.org/10.1161/CIRCULATIONAHA.122.060700, Circulation, 146(20), 1507-1517. Lippincott Williams and Wilkins, Gaziano, L, Sun, L, Arnold, M, Bell, S, Cho, K, Kaptoge, S K, Song, R J, Burgess, S, Posner, D C, Mosconi, K, Robinson-Cohen, C, Mason, A M, Bolton, T R, Tao, R, Allara, E, Schubert, P, Chen, L, Staley, J R, Staplin, N, Altay, S, Amiano, P, Arndt, V, Ärnlöv, J, Barr, E L M, Björkelund, C, Boer, J M A, Brenner, H, Casiglia, E, Chiodini, P, Cooper, J A, Coresh, J, Cushman, M, Dankner, R, Davidson, K W, De Jongh, R T, Donfrancesco, C, Engström, G, Freisling, H, De La Cámara, A G, Gudnason, V, Hankey, G J, Hansson, P O, Heath, A K, Hoorn, E J, Kyrø, C, Nordestgaard, B G, Tjønneland, A, Tybjaerg-Hansen, A, Afzal, S & Emerging Risk Factors Collaboration/EPIC-CVD/Million Veteran Program 2022, ' Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease : Observational and Mendelian Randomization Analyses ', Circulation, vol. 146, no. 20, pp. 1507-1517 . https://doi.org/10.1161/CIRCULATIONAHA.122.060700, Circulation 146, 1507-1517 (2022)
- Publication Year :
- 2022
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2022.
-
Abstract
- Background: End-stage renal disease is associated with a high risk of cardiovascular events. It is unknown, however, whether mild-to-moderate kidney dysfunction is causally related to coronary heart disease (CHD) and stroke. Methods: Observational analyses were conducted using individual-level data from 4 population data sources (Emerging Risk Factors Collaboration, EPIC-CVD [European Prospective Investigation into Cancer and Nutrition–Cardiovascular Disease Study], Million Veteran Program, and UK Biobank), comprising 648 135 participants with no history of cardiovascular disease or diabetes at baseline, yielding 42 858 and 15 693 incident CHD and stroke events, respectively, during 6.8 million person-years of follow-up. Using a genetic risk score of 218 variants for estimated glomerular filtration rate (eGFR), we conducted Mendelian randomization analyses involving 413 718 participants (25 917 CHD and 8622 strokes) in EPIC-CVD, Million Veteran Program, and UK Biobank. Results: There were U-shaped observational associations of creatinine-based eGFR with CHD and stroke, with higher risk in participants with eGFR values 105 mL·min –1 ·1.73 m –2 , compared with those with eGFR between 60 and 105 mL·min –1 ·1.73 m –2 . Mendelian randomization analyses for CHD showed an association among participants with eGFR –1 ·1.73 m –2 , with a 14% (95% CI, 3%–27%) higher CHD risk per 5 mL·min –1 ·1.73 m –2 lower genetically predicted eGFR, but not for those with eGFR >105 mL·min –1 ·1.73 m –2 . Results were not materially different after adjustment for factors associated with the eGFR genetic risk score, such as lipoprotein(a), triglycerides, hemoglobin A1c, and blood pressure. Mendelian randomization results for stroke were nonsignificant but broadly similar to those for CHD. Conclusions: In people without manifest cardiovascular disease or diabetes, mild-to-moderate kidney dysfunction is causally related to risk of CHD, highlighting the potential value of preventive approaches that preserve and modulate kidney function.
- Subjects :
- kidney disease
General Practice
Emerging Risk Factors Collaboration/EPIC-CVD/Million Veteran Program
Coronary Disease
coronary disease
Kidney
Malalties coronàries
1117 Public Health and Health Services
Coronary diseases
SDG 3 - Good Health and Well-being
cardiovascular disease
Risk Factors
Physiology (medical)
Diabetes Mellitus
Humans
Cardiac and Cardiovascular Systems
Prospective Studies
1102 Cardiorespiratory Medicine and Haematology
Kardiologi
Kidney diseases
Malalties cardiovasculars
Cardiovascular Diseases
Kidney Diseases
Stroke
1103 Clinical Sciences
Mendelian Randomization Analysis
kidney diseases
stroke
Allmänmedicin
Cardiovascular diseases
Cardiovascular System & Hematology
Malalties del ronyó
Cardiology and Cardiovascular Medicine
cardiovascular diseases
Subjects
Details
- Language :
- English
- ISSN :
- 00097322
- Database :
- OpenAIRE
- Journal :
- Circulation, 146(20), 1507-1517. Lippincott Williams & Wilkins, Emerging Risk Factors Collaboration/EPIC-CVD/Million Veteran Program 2022, ' Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease : Observational and Mendelian Randomization Analyses ', Circulation, vol. 146, no. 20, pp. 1507-1517 . https://doi.org/10.1161/CIRCULATIONAHA.122.060700, Circulation, 146(20), 1507-1517. Lippincott Williams and Wilkins, Gaziano, L, Sun, L, Arnold, M, Bell, S, Cho, K, Kaptoge, S K, Song, R J, Burgess, S, Posner, D C, Mosconi, K, Robinson-Cohen, C, Mason, A M, Bolton, T R, Tao, R, Allara, E, Schubert, P, Chen, L, Staley, J R, Staplin, N, Altay, S, Amiano, P, Arndt, V, Ärnlöv, J, Barr, E L M, Björkelund, C, Boer, J M A, Brenner, H, Casiglia, E, Chiodini, P, Cooper, J A, Coresh, J, Cushman, M, Dankner, R, Davidson, K W, De Jongh, R T, Donfrancesco, C, Engström, G, Freisling, H, De La Cámara, A G, Gudnason, V, Hankey, G J, Hansson, P O, Heath, A K, Hoorn, E J, Kyrø, C, Nordestgaard, B G, Tjønneland, A, Tybjaerg-Hansen, A, Afzal, S & Emerging Risk Factors Collaboration/EPIC-CVD/Million Veteran Program 2022, ' Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease : Observational and Mendelian Randomization Analyses ', Circulation, vol. 146, no. 20, pp. 1507-1517 . https://doi.org/10.1161/CIRCULATIONAHA.122.060700, Circulation 146, 1507-1517 (2022)
- Accession number :
- edsair.doi.dedup.....d17157dbb2afcb894035ab66f612ff8e