Back to Search
Start Over
Magnesium modifies the association between serum phosphate and the risk of progression to end-stage kidney disease in patients with non-diabetic chronic kidney disease
- Source :
- Kidney International. 88:833-842
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- It is known that magnesium antagonizes phosphate-induced apoptosis of vascular smooth muscle cells and prevents vascular calcification. Here we tested whether magnesium can also counteract other pathological conditions where phosphate toxicity is involved, such as progression of chronic kidney disease (CKD). We explored how the link between the risk of CKD progression and hyperphosphatemia is modified by magnesium status. A post hoc analysis was run in 311 non-diabetic CKD patients who were divided into four groups according to the median values of serum magnesium and phosphate. During a median follow-up of 44 months, 135 patients developed end-stage kidney disease (ESKD). After adjustment for relevant clinical factors, patients in the lower magnesium-higher phosphate group were at a 2.07-fold (95% CI: 1.23–3.48) risk for incident ESKD and had a significantly faster decline in estimated glomerular filtration rate compared with those in the higher magnesium-higher phosphate group. There were no significant differences in the risk of these renal outcomes among the higher magnesium-higher phosphate group and both lower phosphate groups. Incubation of tubular epithelial cells in high phosphate and low magnesium medium in vitro increased apoptosis and the expression levels of profibrotic and proinflammatory cytokine; these changes were significantly suppressed by increasing magnesium concentration. Thus, magnesium may act protectively against phosphate-induced kidney injury.
- Subjects :
- Male
medicine.medical_specialty
Time Factors
Vascular smooth muscle
Renal function
chemistry.chemical_element
Apoptosis
Kaplan-Meier Estimate
Kidney
Cell Line
Phosphates
Proinflammatory cytokine
Kidney Tubules, Proximal
Magnesium Sulfate
Mice
chemistry.chemical_compound
Hyperphosphatemia
Risk Factors
Internal medicine
medicine
Animals
Humans
Magnesium
Renal Insufficiency, Chronic
Membrane Potential, Mitochondrial
business.industry
Protective Factors
Phosphate
medicine.disease
Endocrinology
chemistry
Cytoprotection
Nephrology
Toxicity
Disease Progression
Cytokines
Kidney Failure, Chronic
Female
business
Biomarkers
Glomerular Filtration Rate
Kidney disease
Subjects
Details
- ISSN :
- 00852538
- Volume :
- 88
- Database :
- OpenAIRE
- Journal :
- Kidney International
- Accession number :
- edsair.doi.dedup.....d1703cc26cabcb6fa4b032064d6eac76