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Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior
- Source :
- Tielbeek, J J, Johansson, A, Polderman, T J C, Rautiainen, M-R, Jansen, P, Taylor, M, Tong, X, Lu, Q, Burt, A S, Tiemeier, H, Viding, E, Plomin, R, Martin, N G, Heath, A C, Madden, P A F, Montgomery, G, Beaver, K M, Waldman, I, Gelernter, J, Kranzler, H R, Farrer, L A, Perry, J R B, Munafo, M, LoParo, D, Paunio, T, Tiihonen, J, Mous, S E, Pappa, I, de Leeuw, C, Watanabe, K, Hammerschlag, A R, Salvatore, J E, Aliev, F, Bigdeli, T B, Dick, D, Faraone, S V, Popma, A, Medland, S E & Posthuma, D 2017, ' Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior ', JAMA Psychiatry, vol. 74, no. 12, pp. 1242-1250 . https://doi.org/10.1001/jamapsychiatry.2017.3069, Tielbeek, J J, Johansson, A, Polderman, T J C, Rautiainen, M-R, Jansen, P, Taylor, M, Tong, X, Lu, Q, Burt, A S, Tiemeier, H, Viding, E, Plomin, R, Martin, N G, Heath, A C, Madden, P A F, Montgomery, G, Beaver, K M, Waldman, I, Gelernter, J, Kranzler, H R, Farrer, L A, Perry, J R B, Munafò, M, LoParo, D, Paunio, T, Tiihonen, J, Mous, S E, Pappa, I, de Leeuw, C, Watanabe, K, Hammerschlag, A R, Salvatore, J E, Aliev, F, Bigdeli, T B, Dick, D, Faraone, S V, Popma, A, Medland, S E, Posthuma, D 2017, ' Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior ', JAMA Psychiatry . https://doi.org/10.1001/jamapsychiatry.2017.3069, JAMA Psychiatry, 74(12), 1242-1250. American Medical Association, JAMA psychiatry, 74(12), 1242-1250. American Medical Association, Tielbeek, J J, Johansson, A, Polderman, T J C, Rautiainen, M-R, Jansen, P, Taylor, M, Tong, X, Lu, Q, Burt, A S, Tiemeier, H, Viding, E, Plomin, R, Martin, N G, Heath, A C, Madden, P A F, Montgomery, G, Beaver, K M, Waldman, I, Gelernter, J, Kranzler, H R, Farrer, L A, Perry, J R B, Munafò, M, LoParo, D, Paunio, T, Tiihonen, J, Mous, S E, Pappa, I, de Leeuw, C, Watanabe, K, Hammerschlag, A R, Salvatore, J E, Aliev, F, Bigdeli, T B, Dick, D, Faraone, S V, Popma, A, Medland, S E, Posthuma, D & Broad Antisocial Behavior Consortium collaborators 2017, ' Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior ', JAMA Psychiatry, vol. 74, no. 12, pp. 1242-1250 . https://doi.org/10.1001/jamapsychiatry.2017.3069
- Publication Year :
- 2017
-
Abstract
- Importance: Antisocial behavior (ASB) places a large burden on perpetrators, survivors, and society. Twin studies indicate that half of the variation in this trait is genetic. Specific causal genetic variants have, however, not been identified.Objectives: To estimate the single-nucleotide polymorphism-based heritability of ASB; to identify novel genetic risk variants, genes, or biological pathways; to test for pleiotropic associations with other psychiatric traits; and to reevaluate the candidate gene era data through the Broad Antisocial Behavior Consortium.Design, Setting, and Participants: Genome-wide association data from 5 large population-based cohorts and 3 target samples with genome-wide genotype and ASB data were used for meta-analysis from March 1, 2014, to May 1, 2016. All data sets used quantitative phenotypes, except for the Finnish Crime Study, which applied a case-control design (370 patients and 5850 control individuals).Main Outcome and Measures: This study adopted relatively broad inclusion criteria to achieve a quantitative measure of ASB derived from multiple measures, maximizing the sample size over different age ranges.Results: The discovery samples comprised 16 400 individuals, whereas the target samples consisted of 9381 individuals (all individuals were of European descent), including child and adult samples (mean age range, 6.7-56.1 years). Three promising loci with sex-discordant associations were found (8535 female individuals, chromosome 1: rs2764450, chromosome 11: rs11215217; 7772 male individuals, chromosome X, rs41456347). Polygenic risk score analyses showed prognostication of antisocial phenotypes in an independent Finnish Crime Study (2536 male individuals and 3684 female individuals) and shared genetic origin with conduct problems in a population-based sample (394 male individuals and 431 female individuals) but not with conduct disorder in a substance-dependent sample (950 male individuals and 1386 female individuals) (R2 = 0.0017 in the most optimal model, P = 0.03). Significant inverse genetic correlation of ASB with educational attainment (r = -0.52, P = .005) was detected.Conclusions and Relevance: The Broad Antisocial Behavior Consortium entails the largest collaboration to date on the genetic architecture of ASB, and the first results suggest that ASB may be highly polygenic and has potential heterogeneous genetic effects across sex.
- Subjects :
- Male
0301 basic medicine
Multifactorial Inheritance
Candidate gene
Finland/epidemiology
Genome-wide association study
Brain and Behaviour
0302 clinical medicine
Child
10. No inequality
Finland
Genetics
education.field_of_study
Tobacco and Alcohol
Antisocial Personality Disorder
Middle Aged
16. Peace & justice
Justice and Strong Institutions
Psychiatry and Mental health
Conduct disorder
Female
Adult
Conduct Disorder
SDG 16 - Peace
Adolescent
Population
Environment
Biology
Article
03 medical and health sciences
Sex Factors
medicine
Journal Article
Humans
Antisocial Personality Disorder/epidemiology
Conduct Disorder/epidemiology
education
Antisocial personality disorder
SDG 16 - Peace, Justice and Strong Institutions
Genetic Variation
Heritability
medicine.disease
Twin study
ta3124
Genetic architecture
030104 developmental biology
030217 neurology & neurosurgery
Genome-Wide Association Study
Demography
Subjects
Details
- Language :
- English
- ISSN :
- 2168622X
- Database :
- OpenAIRE
- Journal :
- Tielbeek, J J, Johansson, A, Polderman, T J C, Rautiainen, M-R, Jansen, P, Taylor, M, Tong, X, Lu, Q, Burt, A S, Tiemeier, H, Viding, E, Plomin, R, Martin, N G, Heath, A C, Madden, P A F, Montgomery, G, Beaver, K M, Waldman, I, Gelernter, J, Kranzler, H R, Farrer, L A, Perry, J R B, Munafo, M, LoParo, D, Paunio, T, Tiihonen, J, Mous, S E, Pappa, I, de Leeuw, C, Watanabe, K, Hammerschlag, A R, Salvatore, J E, Aliev, F, Bigdeli, T B, Dick, D, Faraone, S V, Popma, A, Medland, S E & Posthuma, D 2017, ' Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior ', JAMA Psychiatry, vol. 74, no. 12, pp. 1242-1250 . https://doi.org/10.1001/jamapsychiatry.2017.3069, Tielbeek, J J, Johansson, A, Polderman, T J C, Rautiainen, M-R, Jansen, P, Taylor, M, Tong, X, Lu, Q, Burt, A S, Tiemeier, H, Viding, E, Plomin, R, Martin, N G, Heath, A C, Madden, P A F, Montgomery, G, Beaver, K M, Waldman, I, Gelernter, J, Kranzler, H R, Farrer, L A, Perry, J R B, Munafò, M, LoParo, D, Paunio, T, Tiihonen, J, Mous, S E, Pappa, I, de Leeuw, C, Watanabe, K, Hammerschlag, A R, Salvatore, J E, Aliev, F, Bigdeli, T B, Dick, D, Faraone, S V, Popma, A, Medland, S E, Posthuma, D 2017, ' Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior ', JAMA Psychiatry . https://doi.org/10.1001/jamapsychiatry.2017.3069, JAMA Psychiatry, 74(12), 1242-1250. American Medical Association, JAMA psychiatry, 74(12), 1242-1250. American Medical Association, Tielbeek, J J, Johansson, A, Polderman, T J C, Rautiainen, M-R, Jansen, P, Taylor, M, Tong, X, Lu, Q, Burt, A S, Tiemeier, H, Viding, E, Plomin, R, Martin, N G, Heath, A C, Madden, P A F, Montgomery, G, Beaver, K M, Waldman, I, Gelernter, J, Kranzler, H R, Farrer, L A, Perry, J R B, Munafò, M, LoParo, D, Paunio, T, Tiihonen, J, Mous, S E, Pappa, I, de Leeuw, C, Watanabe, K, Hammerschlag, A R, Salvatore, J E, Aliev, F, Bigdeli, T B, Dick, D, Faraone, S V, Popma, A, Medland, S E, Posthuma, D & Broad Antisocial Behavior Consortium collaborators 2017, ' Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior ', JAMA Psychiatry, vol. 74, no. 12, pp. 1242-1250 . https://doi.org/10.1001/jamapsychiatry.2017.3069
- Accession number :
- edsair.doi.dedup.....d17039f61f7bb1dde41ec574023c8322