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Calcineurin signaling as a target for the treatment of alcohol abuse and neuroinflammatory disorders
- Source :
- Prog Mol Biol Transl Sci
- Publication Year :
- 2019
- Publisher :
- Elsevier, 2019.
-
Abstract
- Converging lines of evidence point to a significant role of neuroinflammation in a host of psychiatric conditions, including alcohol use disorder, TBI, and PTSD. A complex interaction of both peripheral and central signaling underlies processes involved in neuroinflammation. Calcineurin is a molecule that sits at the nexus of these processes and has been clearly linked to a number of psychiatric disorders including alcohol use disorder (AUD). Like its role in regulating peripheral immune cells, calcineurin (CN) plays an integral role in processes regulating neuroimmune function and neuroinflammatory processes. Targeting CN or elements of its signaling pathways at critical points may aid in the functional recovery from neuroinflammatory related disorders. In this review we will highlight the role of neuroinflammation and calcineurin signaling in AUD, TBI and stress-induced disorders and discuss recent findings demonstrating a therapeutic effect of immunosuppressant-induced calcineurin inhibition in a pre-clinical model of binge alcohol drinking.
- Subjects :
- Traumatic brain injury
Alcohol abuse
Alcohol use disorder
Article
03 medical and health sciences
0302 clinical medicine
Immune system
Animals
Humans
Medicine
Neuroinflammation
030304 developmental biology
Inflammation
0303 health sciences
Calcineurin signaling
business.industry
Calcineurin
medicine.disease
Alcoholism
Nervous System Diseases
Signal transduction
business
Neuroscience
Immunosuppressive Agents
030217 neurology & neurosurgery
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Prog Mol Biol Transl Sci
- Accession number :
- edsair.doi.dedup.....d167bcab53fc533a201aca7cef6245f5