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Effects of dietary protein on teratogenicity of ochratoxin A in rats
Effects of dietary protein on teratogenicity of ochratoxin A in rats
- Source :
- Toxicology. 27(2)
- Publication Year :
- 1983
-
Abstract
- The teratogenic effects of a single subcutaneous dose of 1.75 mg/kg ochratoxin A given on day 6 of gestation was compared in weanling rats fed 5% protein diet for 4 weeks followed by normal protein diet (referred to as 5% normal protein diets) for the remainder of the experimental period, rats maintained on 10% protein diet, and rats on a normal protein diet throughout. These different diets are based on total dietary concentration of protein. Of the rats fed 10% protein diet, 22% failed to mate and in 39% failure of fertilization was observed. In rats fed 5% normal protein diets, the fertilization rate was 100%. Ochratoxin A treatment resulted in significant depression of fetal body weight in rats fed 5% normal protein diets and in rats maintained on normal protein diet throughout. Significant numbers of malformations (gross and skeletal) occurred in all the treated groups. Rats on a 5% normal protein diet and rats on the normal diet yielded a significant number of fetuses with internal soft tissue anomalies. The highest incidence of skeletal malformations occurred in ochratoxin A treated rats maintained on 10% protein diet throughout the experiment. Complete rehabilitation took place by replacement of low protein diet with normal protein diet.
- Subjects :
- Ochratoxin A
medicine.medical_specialty
Normal diet
medicine.medical_treatment
Weanling
Biology
Toxicology
Bone and Bones
chemistry.chemical_compound
Human fertilization
Low-protein diet
Pregnancy
Internal medicine
Protein Deficiency
medicine
Animals
Fetus
Body Weight
Fetal Body Weight
Abnormalities, Drug-Induced
Rats, Inbred Strains
Ochratoxins
Rats
Endocrinology
chemistry
Gestation
Female
Dietary Proteins
Subjects
Details
- ISSN :
- 0300483X
- Volume :
- 27
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Toxicology
- Accession number :
- edsair.doi.dedup.....d1607d1d158547178acef94ea3b3a3c3