Confirmed Invasive Pulmonary Aspergillosis and COVID-19: the value of postmortem findings to support antemortem management

Authors :: André de Lima Guerra Corado
Gisely Cardoso de Melo
Mayla Gabriela Silva Borba
Márcia A. A. Alexandre
George Alan Villarouco Siva
Wuelton Marcelo Monteiro
João Vicente Braga de Souza
Jose Diego Brito-Sousa
Silviane Bezerra Pinheiro
Ludhmila Abrahão Hajjar
Marcus V. G. Lacerda
Guilherme Pivoto
Valdinete Alves do Nascimento
Alessandro C. Pasqualotto
Fernando Fonseca Almeida Val
Luiz Carlos de Lima Ferreira
Djane Clarys Baia-da-Silva
Monique Freire Santana
Felipe Gomes Naveca
João Ricardo da Silva Neto
Source :: Revista da Sociedade Brasileira de Medicina Tropical, Revista da Sociedade Brasileira de Medicina Tropical, Vol 53 (2020)
Publication Year :: 2020
Publisher :: Sociedade Brasileira de Medicina Tropical - SBMT, 2020.
Abstract: We present postmortem evidence of invasive pulmonary aspergillosis (IPA) in a patient with severe COVID-19. Autopsies of COVID-19 confirmed cases were performed. The patient died despite antimicrobials, mechanical ventilation, and vasopressor support. Histopathology and peripheral blood galactomannan antigen testing confirmed IPA. Aspergillus penicillioides infection was confirmed by nucleotide sequencing and BLAST analysis. Further reports are needed to assess the occurrence and frequency of IPA in SARS-CoV-2 infections, and how they interact clinically.

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