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Lipoprotein lipase activity in skeletal muscles of the rat: effects of denervation and tenotomy
- Source :
- ResearcherID, Scopus-Elsevier
-
Abstract
- The effects of denervation, tenotomy, or tenotomy with simultaneous denervation on the activity of heparin-releasable and intracellular, residual lipoprotein lipase (LPL) and triacylglycerol (TG) content were examined in rat skeletal muscles. An influence of muscle electrostimulation on denervated and tenotomized muscles was also evaluated. Activity of both LPL fractions was decreased in denervated and/or tenotomized soleus and red portion of gastrocnemius muscles. It was accompanied by a slight elevation of the intracellular TG content. Electrostimulation increased activities of both fractions of LPL in red muscles from intact hindlimbs. In stimulated denervated muscles without or with simultaneous tenotomy, activity of two LPL fractions was also enhanced, but control values were reached only in denervated soleus muscle. Electrical stimulation had no pronounced effect on LPL activity in tenotomized muscles. In conclusion, denervation and/or tenotomy decreases LPL activity in red muscles, indicating reduction of the muscle potential to utilize circulating TG. Electrostimulation only partly restores the diminished LPL activity in denervated muscles, without any effect in tenotomized ones. Thus, to maintain LPL activity in resting muscle, intact innervation and tension are needed.
- Subjects :
- Male
medicine.medical_specialty
Physiology
medicine.medical_treatment
Tenotomy
Stimulation
Biology
In Vitro Techniques
Achilles Tendon
Tendons
Gastrocnemius muscle
Physiology (medical)
Internal medicine
medicine
Lipolysis
Animals
Rats, Wistar
Muscle, Skeletal
Triglycerides
Soleus muscle
Denervation
Lipoprotein lipase
nutritional and metabolic diseases
Anatomy
Sciatic Nerve
Electric Stimulation
Muscle Denervation
Hindlimb
Rats
Lipoprotein Lipase
Endocrinology
Muscle Fibers, Fast-Twitch
lipids (amino acids, peptides, and proteins)
Intracellular
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- ResearcherID, Scopus-Elsevier
- Accession number :
- edsair.doi.dedup.....d14ca089a452933a1d33dc38b699671b