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Efficacy and safety of rufinamide as adjunctive therapy in patients with Lennox Gastaut syndrome: A systematic review and Meta-analysis
- Source :
- Seizure. 91:296-307
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Rufinamide is an antiseizure medication that acts through sodium channels and is found to be efficacious in patients with Lennox Gastaut syndrome (LGS). However, no systematic review has been conducted in LGS patients to provide an estimate of the efficacy and safety of rufinamide.Different electronic databases were searched for articles describing the use of rufinamide in patients with LGS. For determining primary efficacy outcomes as compared to placebo, we included only studies comparing the efficacy of rufinamide with placebo in LGS patients. We performed an additional analysis to include other uncontrolled studies with a minimum sample size of 20 to provide a more comprehensive estimate of efficacy.A total of ten studies included 557 patients. Out of them, five studies were placebo-controlled, enrolling a total of 265 patients in the rufinamide group and 203 patients in the placebo group. The average percentage reduction in total seizure frequency per 28 days during the double-blind phase was 29.3% in the rufinamide group compared with 8.3% in the placebo group (difference between the two groups was 20.9%, 95%CI-14.4%-27.3%, p0.00001). Even for individual seizure types like tonic-clonic seizures, atypical absence seizures, atonic seizures, focal seizures, and myoclonic seizures, rufinamide was more efficacious than placebo(p0.00001). The number of patients with at least one treatment-emergent adverse effects was significantly higher in rufinamide treated patients (60.2%vs50.7%, p=0.02, RR-1.24(1.03,1.51).Rufinamide is efficacious as adjunctive therapy in patients with LGS in terms of reduction in total seizure frequency and has mild adverse reaction.
- Subjects :
- medicine.medical_specialty
Lennox Gastaut Syndrome
business.industry
General Medicine
Rufinamide
Triazoles
Drug Resistant Epilepsy
Placebo
medicine.disease
Epilepsy
Neurology
Seizures
Sample size determination
Meta-analysis
Internal medicine
medicine
Humans
Anticonvulsants
Neurology (clinical)
business
Adverse effect
Randomized Controlled Trials as Topic
medicine.drug
Lennox–Gastaut syndrome
Subjects
Details
- ISSN :
- 10591311
- Volume :
- 91
- Database :
- OpenAIRE
- Journal :
- Seizure
- Accession number :
- edsair.doi.dedup.....d1450c0aada8f325a746cbf17948adc4