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Association of cardiac magnetic resonance‐detected myocardial abnormalities with disease characteristics and brain natriuretic peptide levels in systemic sclerosis without cardiac symptoms
- Source :
- International Journal of Rheumatic Diseases.
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- Aim This study aimed to evaluate the association between myocardial abnormalities and left ventricular (LV) geometry as assessed using cardiac magnetic resonance imaging (CMRI) in systemic sclerosis (SSc) patients without cardiac symptoms. Methods SSc patients without cardiac symptoms or cardiovascular risk factors underwent contrast CMRI. CMRI were assessed for structural and functional LV parameters and myocardial fibrosis based on myocardial late gadolinium enhancement (LGE). The correlation between brain natriuretic peptide (BNP) levels and LGE status was evaluated. Results Among 49 patients, 27 (55%) showed LGE positivity. The most common identified LGE pattern was a linear pattern. LGE was not consistent with coronary artery distribution. There was no difference in ejection fraction between those with and without LGE. LV morphological changes were observed in 29% of SSc patients. An abnormal LV structure was detected in 44% and 14% of patients in the LGE+ and LGE- groups, respectively. The BNP levels were higher by 57% in the LGE+ group than in the LGE-group. Receiver operating characteristic analysis showed that BNP levels reliably detected myocardial abnormalities (area under the curve, 0.72; 95% confidence interval 0.58-0.88). Conclusions Myocardial abnormalities were common in SSc patients without cardiac symptoms. We suggest that LV morphological changes may have resulted from myocardial abnormalities. BNP may be useful as a screening tool for the detection of myocardial abnormalities in SSc patients.
- Subjects :
- Male
medicine.medical_specialty
Magnetic Resonance Imaging, Cine
Risk Assessment
Ventricular Function, Left
Japan
Rheumatology
Predictive Value of Tests
Risk Factors
Cardiac magnetic resonance imaging
Internal medicine
Natriuretic Peptide, Brain
Prevalence
medicine
Humans
cardiovascular diseases
Retrospective Studies
Scleroderma, Systemic
Ejection fraction
Ventricular Remodeling
medicine.diagnostic_test
business.industry
Myocardium
Area under the curve
Middle Aged
Prognosis
Brain natriuretic peptide
Fibrosis
Confidence interval
medicine.anatomical_structure
Asymptomatic Diseases
embryonic structures
Cardiology
Female
Hypertrophy, Left Ventricular
Myocardial fibrosis
business
Biomarkers
Cardiac symptoms
Artery
Subjects
Details
- ISSN :
- 1756185X and 17561841
- Database :
- OpenAIRE
- Journal :
- International Journal of Rheumatic Diseases
- Accession number :
- edsair.doi.dedup.....d1426eab34471ce0f3c7c8fa2be29ced