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HBME-1 expression in hyalinizing trabecular tumours of the thyroid gland
- Source :
- Histopathology. 62:1092-1097
- Publication Year :
- 2013
- Publisher :
- Wiley, 2013.
-
Abstract
- Aims Hyalinizing trabecular tumour (HTT) is a rare thyroid neoplasm with a trabecular growth pattern, marked intratrabecular hyalinization and nuclear features of papillary thyroid carcinoma (PTC). Immunohistochemical HBME-1 expression was reported recently in PTC, but not in HTT. To clarify further the value of HBME-1 expression as a tool in differential diagnosis, we investigated the immunophenotype of HTT. Methods and results Eight HTT diagnosed from 1997 to 2012 were reviewed on H&E-stained tissue sections and analysed for HBME-1, galectin-3, CK19 and Ki67 expression by immunohistochemistry. Three of eight HTTs (37.5%) were HBME-1 positive, with staining of tumour cells as well as of intratrabecular hyaline matrix material. All cases were CK19 negative. Galectin-3 was expressed weakly in four of eight cases (50%). Five of eight cases (62.5%) showed weak-to-moderate cytoplasmic Ki67 positivity. Conclusions Immunohistochemical HBME-1 expression is present in HTT and may not serve as a reliable marker in differentiating HTT from PTC. The HBME-1 positivity of the hyaline matrix suggests that this material is partly of cytoplasmic origin.
- Subjects :
- Adult
Male
Hyalin
Pathology
medicine.medical_specialty
Histology
Thyroid Gland
610 Medicine & health
Biology
medicine.disease_cause
2722 Histology
Pathology and Forensic Medicine
Thyroid carcinoma
Immunophenotyping
10049 Institute of Pathology and Molecular Pathology
mental disorders
Biomarkers, Tumor
medicine
Carcinoma
Humans
Thyroid Neoplasms
Thyroid cancer
Thyroid neoplasm
Hyaline
Aged
Thyroid
General Medicine
Middle Aged
medicine.disease
Carcinoma, Papillary
2734 Pathology and Forensic Medicine
medicine.anatomical_structure
Thyroid Cancer, Papillary
Immunohistochemistry
Female
Subjects
Details
- ISSN :
- 03090167
- Volume :
- 62
- Database :
- OpenAIRE
- Journal :
- Histopathology
- Accession number :
- edsair.doi.dedup.....d13f8e9761695019365293d08d757241