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Weekly Chemotherapy with Cisplatin and Paclitaxel and Concurrent Radiation Therapy as Preoperative Treatment in Locally Advanced Esophageal Cancer: A Phase II Study
- Source :
- Cancer investigation 28 (2010): 820–827., info:cnr-pdr/source/autori:Orditura, M; Galizia, G; Napolitano, V; Martinelli, E; Pacelli, R; Lieto, E; Aurilio, G; Vecchione, L; Morgillo, F; Catalano, G; Ciardiello, F; Del Genio, A; Di Martino, N; De Vita, F/titolo:Weekly Chemotherapy with Cisplatin and Paclitaxel and Concurrent Radiation Therapy as Preoperative Treatment in Locally Advanced Esophageal Cancer: A Phase II Study/doi:/rivista:Cancer investigation/anno:2010/pagina_da:820/pagina_a:827/intervallo_pagine:820–827/volume:28
- Publication Year :
- 2010
- Publisher :
- Marcel Dekker, [New York, N.Y.] , Stati Uniti d'America, 2010.
-
Abstract
- We evaluated the association of a weekly cisplatin (35 mg/mq) and paclitaxel (45 mg/mq) regimen with radiotherapy (46 Gy) as primary treatment in locally advanced esophageal cancer (LAEC). The main end point was the activity in terms of pathologic complete response (pathCR) rate. Thirty-three LAEC patients received chemoradiation therapy during weeks 1-6 followed by esophagectomy. A pathCR was observed in 10/33 patients; 20/33 and 3/33 patients showed PR and SD, respectively. The EUS maximal transverse cross sectional area reduction >50 significantly correlated with pathCR. Three-year survival rate was 35%. These results support the activity and mild toxicity of this regimen. © 2010 Informa Healthcare USA, Inc.
- Subjects :
- Oncology
Adult
Male
Cancer Research
medicine.medical_specialty
Time Factors
Esophageal Neoplasms
Paclitaxel
medicine.medical_treatment
Biopsy
Esophageal cancer
Urology
Phases of clinical research
Preoperative chemoradiotherapy
Adenocarcinoma
Drug Administration Schedule
chemistry.chemical_compound
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Survival rate
Aged
Neoplasm Staging
Cisplatin
Radiotherapy
business.industry
Platelet Count
Patient Selection
General Medicine
Middle Aged
medicine.disease
Prognosis
Combined Modality Therapy
Radiation therapy
Esophagectomy
Survival Rate
Regimen
chemistry
Carcinoma, Squamous Cell
Female
business
medicine.drug
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Cancer investigation 28 (2010): 820–827., info:cnr-pdr/source/autori:Orditura, M; Galizia, G; Napolitano, V; Martinelli, E; Pacelli, R; Lieto, E; Aurilio, G; Vecchione, L; Morgillo, F; Catalano, G; Ciardiello, F; Del Genio, A; Di Martino, N; De Vita, F/titolo:Weekly Chemotherapy with Cisplatin and Paclitaxel and Concurrent Radiation Therapy as Preoperative Treatment in Locally Advanced Esophageal Cancer: A Phase II Study/doi:/rivista:Cancer investigation/anno:2010/pagina_da:820/pagina_a:827/intervallo_pagine:820–827/volume:28
- Accession number :
- edsair.doi.dedup.....d13325dfc7c131694d9970f4aac39bf9