PATHOLOGY AND NOSOLOGY OF HODGKIN'S DISEASE

Lymphogranuloma is not localized and only linked with the RS in so far as its cells are of retothelial origin. Differentiation of the characteristic histological pattern has shown that the histogenesis of the lymphogranulomatous focus, with empty necrobiosis, granuloma formation and sclerotic obliteration, corresponds to the regular biopathological phases of inflammation. As a reactive process of varied duration and degree, lymphogranulomatosis can present various, including tumor-like changes, without satisfying the histological criteria of auto-nomous neoplasia or prospective sarcoma. Even though the etiology of Hodgkin's disease is unknown, it is clinically, anatomically and histologically a separate disease. A survey of the various morphological findings leads to classifying it as an inflammation. It may be that the Hodgkin's disease, like rheumatic diseases, nephritis or lupus erythematosus, is a poly-etiological reaction product, a course emancipated from the cause and proceeding by its own laws.