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Clinical characteristics and tumor markers in ischemic stroke patients with active cancer
- Source :
- Internal and Emergency Medicine. 17:735-741
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Cancer-associated ischemic stroke (CAS) refers to a hypercoagulation disorder related to malignant tumors, especially adenocarcinoma. Carbohydrate antigen (CA) 125 is a mucinous serum marker that might reflect hypercoagulation status, but the association between CA 125 and CAS is unclear across various types of cancer. The aim of this study was to investigate the associations among tumor markers, coagulation markers, and clinical factors in acute ischemic stroke (AIS) patients with active cancer. Consecutive AIS patients with active cancer (a diagnosis or ongoing active therapy for cancer within 6 months) were prospectively enrolled at four hospitals. D-dimer, C-reactive protein (CRP), carcinoembryonic antigen (CEA), CA19-9, and CA 125 levels were measured. Of 120 AIS patients with active cancer, 47 were diagnosed with CAS. CA 125 had the strongest correlations with D-dimer and CRP (ρ = 0.543, p
- Subjects :
- medicine.medical_specialty
CA-19-9 Antigen
Gastroenterology
Carcinoembryonic antigen
Neoplasms
Internal medicine
D-dimer
Biomarkers, Tumor
Internal Medicine
medicine
Humans
Thrombophilia
Ischemic Stroke
biology
business.industry
Cancer
Atrial fibrillation
medicine.disease
Carcinoembryonic Antigen
Stroke
C-Reactive Protein
Quartile
CA-125 Antigen
Ischemic stroke
Emergency Medicine
biology.protein
Adenocarcinoma
business
Dyslipidemia
Subjects
Details
- ISSN :
- 19709366 and 18280447
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Internal and Emergency Medicine
- Accession number :
- edsair.doi.dedup.....d0ffd29b4571693ce234c19d972641a8