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Association of Metformin, Other Antidiabetic Medications, and Statins With Incidence of Colon Cancer in Patients With Type 2 Diabetes
- Source :
- Clinical Colorectal Cancer. 20:e113-e119
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Background Metformin and statins may have anticancer effects, with plausible cellular mechanisms. However, the association of these agents with the risk of colorectal cancer is unclear. Patients and Methods This was a retrospective cohort study on a large population (N = 316,317) of patients with type 2 diabetes. Data were obtained from the Diabetes in Finland database (FinDM). In a full cohort analysis, hazard ratios (HRs) with their 95% confidence intervals (CIs) for ever use versus never use were estimated using a multiple Poisson regression model. A nested case–control design within the cohort was used to examine the association of colon cancer (CC) with the defined daily dose of medication. The data were analyzed by conditional logistic regression. The analyses were adjusted for the patient’s age, sex, and duration of diabetes. Results In total, 1351 CC cases were diagnosed during 1996-2011. The results revealed insufficient evidence for an association between metformin (HR, 1.01; 95% CI, 0.90-1.14), other oral antidiabetic medications (HR, 1.05; 95% CI, 0.93-1.19), insulin (HR, 1.02; 95% CI, 0.86-1.22), or statins (HR, 0.94; 95% CI, 0.84-1.05) and the incidence of CC in the full cohort analysis. The results from the case–control study were similar, with no consistent trend in the incidence of CC according to the cumulative dose of metformin or the other studied medications. Conclusion This study found insufficient evidence for an association between metformin, insulin, other oral type 2 diabetes medications, or statins and the incidence of CC.
- Subjects :
- Adult
Male
medicine.medical_specialty
Epidemiology
Type 2 diabetes
03 medical and health sciences
0302 clinical medicine
Internal medicine
Diabetes mellitus
medicine
Humans
Hypoglycemic Agents
Insulin
Aged
Retrospective Studies
business.industry
Incidence
Hazard ratio
Cohort
Gastroenterology
Retrospective cohort study
Middle Aged
medicine.disease
Colorectal cancer
Metformin
Nested case–control
Diabetes Mellitus, Type 2
Oncology
Case-Control Studies
030220 oncology & carcinogenesis
Colonic Neoplasms
Nested case-control study
030211 gastroenterology & hepatology
business
medicine.drug
Cohort study
Subjects
Details
- ISSN :
- 15330028
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Clinical Colorectal Cancer
- Accession number :
- edsair.doi.dedup.....d0ea0386e15be3575a56184094f92684