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THE RÒ‚LE OF THE RETICULO-ENDOTHELIAL SYSTEM IN IMMUNITY
- Source :
- The Journal of Experimental Medicine
- Publication Year :
- 1926
- Publisher :
- Rockefeller University Press, 1926.
-
Abstract
- 1. Guinea pigs injected intravenously with massive doses of India ink before active sensitization exhibited occasionally a more or less marked, decreased sensitiveness to the reinjection of the antigen. 2. The serum of rabbits which had received massive doses of India ink before the sensitizing injections, showed approximately the same titer of anaphylactic antibodies as that of sensitized normal control animals, as demonstrated by the degree of passive sensitization induced in guinea pigs. 3. The precipitin titer of sensitized rabbits blocked with massive doses of India ink was somewhat lower than that of sensitized normal controls. In one instance, the intravenous injection of smaller doses of India ink was followed by a higher precipitin titer. No uniform relation was found between the height of the precipitin titer and the anaphylactic power of the antiserums. 4. One blocking injection of India ink given to guinea pigs before passive sensitization did not interfere with the occurrence of anaphylactic shock nor alter its nature.
- Subjects :
- Pathology
medicine.medical_specialty
Endothelium
Immunology
Caviidae
Spleen
Pharmacology
complex mixtures
Article
Andrology
Guinea pig
Subcutaneous injection
Blood serum
Antigen
Immunity
Respiration
Immunology and Allergy
Medicine
Sensitization
biology
business.industry
Diphtheria
biology.organism_classification
medicine.disease
Precipitin
In vitro
Blockade
Titer
medicine.anatomical_structure
Immunization
biology.protein
Antitoxin
Antibody
business
Anaphylaxis
Subjects
Details
- ISSN :
- 15409538 and 00221007
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- Journal of Experimental Medicine
- Accession number :
- edsair.doi.dedup.....d0e8d8e824725fe9b7c53d1f59dfe35b