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Imaging the structure of the striatum: a fractal approach to SPECT image interpretation
- Source :
- Physiological Measurement. 19:367-374
- Publication Year :
- 1998
- Publisher :
- IOP Publishing, 1998.
-
Abstract
- The spatial pattern of striatal dopamine transporter density in the living human brain was tested by duplicate SPECT scans with , or and striatal phantom measurements. The resolution-dependent spatial variation was calculated by the fractal analysis of SPECT images. This variation, which depends on the size of the region of interest, was described by the spatial dispersion i.e. the standard deviation of the count densities divided by the mean density. In each sub-region, the observed and methodological dispersions were computed, and the resulting spatial dispersion was calculated. The methodological dispersion is caused by the imaging resolution, flood field non-uniformity, count density, scatter, reconstruction errors and partial volume effects, whereas the spatial dispersion is based on the cerebral heterogeneity of the dopamine transporter density. Recognition of the normal variation in heterogeneity is important in evaluation of the striatal dopamine transporter density between controls and patients suffering from various neuropsychiatric disorders. Keywords: fractal, heterogeneity, receptor, SPECT, striatum
- Subjects :
- Adult
Physiology
Physics::Medical Physics
Biomedical Engineering
Biophysics
Partial volume
Standard deviation
Imaging phantom
Fractal
Nuclear magnetic resonance
Region of interest
Physiology (medical)
Image Processing, Computer-Assisted
Humans
Dopamine transporter
Tomography, Emission-Computed, Single-Photon
Physics
Quantitative Biology::Neurons and Cognition
biology
business.industry
Middle Aged
Fractal analysis
Corpus Striatum
biology.protein
Spatial variability
Nuclear medicine
business
Subjects
Details
- ISSN :
- 13616579 and 09673334
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Physiological Measurement
- Accession number :
- edsair.doi.dedup.....d0e78fd352c8b718b446d4cf62b0bc04