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Soluble mediators in anti-fungal immunity

Authors :: Sarah Sze Wah Wong
Vishukumar Aimanianda
Sarah Dellière
Mycologie moléculaire - Molecular Mycology
Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)
Laboratoire de Parasitologie-Mycologie [CHU Saint Louis, Paris]
Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris]
Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
SSWW is supported by Pasteur-Roux-Cantarini fellowship.
Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)
Source :: Current Opinion in Microbiology, Current Opinion in Microbiology, Elsevier, 2020, 58, pp.24-31. ⟨10.1016/j.mib.2020.05.005⟩, Current Opinion in Microbiology, 2020, 58, pp.24-31. ⟨10.1016/j.mib.2020.05.005⟩
Publication Year :: 2020
Publisher :: Elsevier BV, 2020.
Abstract: International audience; Although soluble mediators of our innate immune system have a substantial impact on invading microbes, their role against fungal pathogens has been underexplored. Constituting the humoral immunity, soluble mediators comprise the complement system, collectins, acute-phase proteins, antibodies and antimicrobial peptides. These components can prevent fungal infection either by directly interacting with invading microbes, leading to their aggregation (microbistatic), destruction (microbicidal) or linking them to cellular immunity. The composition of soluble-mediator varies with human body-fluids, resulting in different antifungal mechanisms. Moreover, cellular immune system deploys both oxidative and non-oxidative mechanisms to destroy extracellular or internalized fungal pathogens; however, cellular immune activation is mainly influenced as well as regulated by soluble mediators. This review outlines the antifungal mechanism employed, directly or indirectly, by soluble mediators, and in response, the evading strategies of the fungal pathogens.