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A Decade of Tau Transgenic Animal Models and Beyond
- Source :
- Brain Pathol
- Publication Year :
- 2007
- Publisher :
- Blackwell Publishing Ltd, 2007.
-
Abstract
- The first tau transgenic mouse model was established more than a decade ago. Since then, much has been learned about the role of tau in Alzheimer's disease and related disorders. Animal models, both in vertebrates and invertebrates, were significantly improved and refined as a result of the identification of pathogenic mutations in Tau in human cases of frontotemporal dementia. They have been instrumental for dissecting the cross-talk between tau and the second hallmark lesion of Alzheimer's disease, the Abeta peptide-containing amyloid plaque. We discuss how the tau models have been used to unravel the pathophysiology of Alzheimer's disease, to search for disease modifiers and to develop novel treatment strategies. While tau has received less attention than Abeta, it is rapidly acquiring a more prominent position and the emerging view is one of a synergistic action of Abeta and tau in Alzheimer's disease. Moreover, the existence of a number of neurodegenerative diseases with tau pathology in the absence of extracellular deposits underscores the relevance of research on tau.
- Subjects :
- Genetically modified mouse
Tau pathology
General Neuroscience
Transgene
Mice, Transgenic
tau Proteins
Disease
Biology
medicine.disease
Pathology and Forensic Medicine
Animals, Genetically Modified
Disease Models, Animal
Mice
Alzheimer Disease
mental disorders
medicine
Treatment strategy
Animals
Dementia
Drosophila
Neurology (clinical)
Neuroscience
SYMPOSIUM: Tau Protein and Neurodegeneration
Frontotemporal dementia
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Brain Pathol
- Accession number :
- edsair.doi.dedup.....d0dc40664b1b4f228a3cca0390f4523c