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Post-prandial Remnant Lipoprotein Metabolism in Sitosterolemia
- Source :
- Journal of Atherosclerosis and Thrombosis
- Publication Year :
- 2018
- Publisher :
- 日本動脈硬化学会 = Japan Atherosclerosis Society, 2018.
-
Abstract
- 金沢大学附属病院循環器内科<br />Aim: We aimed to clarify post-prandial accumulation of remnant-like particles (RLP) in patients with sitosterolemia.\nMethods: Oral fat tolerance test cream (Jomo Shokuhin, Takasaki, Japan) 50 g was given per body surface area (m2); blood sampling was performed at 2 h intervals up to 6 h. Plasma lipoprotein fractions and RLP fractions were determined in four sitosterolemic subjects with double mutations in ATP-binding cassette (ABC) sub-family G member 5 or member 8 (ABCG5 or ABCG8) gene (mean age=18 yr, median low-density lipoprotein cholesterol [LDL-C]=154 mg/dL), six heterozygous carriers (mean age=31 yr, median LDL-C=105 mg/dL), and five subjects with heterozygous familial hypercholesterolemia (FH, mean age=32 yr, median LDL-C=221 mg/dL). The incremental area under curve (iAUC) of lipids, including LDL-C, apolipoprotein B-48 (apoB48), RLP cholesterol (RLP-C), and RLP triglyceride (RLP-TG) were evaluated.\nResults: After oral fat load, there was no significant difference of the iAUC of LDL-C between sitosterolemia and heterozygous FH, whereas the iAUC of apoB48 was significantly larger in the sitosterolemic subjects compared with that of heterozygous FH (2.9 µg/mL×h vs. 1.3 µg/mL×h, p<0.05). Under these conditions, the iAUCs of RLP-C and RLP-TG levels were significantly larger in the sitosterolemic subject compared with those of heterozygous FH (9.5 mg/dL×h vs. 5.7 mg/dL×h, p<0.05; 149 mg/dL×h vs. 40 mg/dL×h, p<0.05, respectively), whereas those of heterozygous carriers were comparable with those with heterozygous FH.\nConclusions: Post-prandial lipoprotein metabolism in sitosterolemia appeared to be impaired, leading to their elevation in serum sterol levels. (UMIN Clinical Trials Registry number, UMIN000020330)<br />This article distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.
- Subjects :
- Male
0301 basic medicine
Apolipoprotein B
Familial hypercholesterolemia
030204 cardiovascular system & hematology
chemistry.chemical_compound
0302 clinical medicine
Japan
Remnant
OFTT
biology
Incidence
Phytosterols
Postprandial Period
Prognosis
Remnant-like-particles
Cholesterol
ABCG5
Female
Original Article
Cardiology and Cardiovascular Medicine
Sitosterolemia
Adult
Heterozygote
medicine.medical_specialty
Adolescent
Lipoproteins
Hypercholesterolemia
ABCG8
Lipid Metabolism, Inborn Errors
03 medical and health sciences
Internal medicine
Internal Medicine
medicine
Humans
Triglycerides
Triglyceride
business.industry
Biochemistry (medical)
medicine.disease
Intestinal Diseases
030104 developmental biology
Endocrinology
chemistry
biology.protein
business
Biomarkers
Follow-Up Studies
Blood sampling
Subjects
Details
- Language :
- English
- ISSN :
- 13403478
- Volume :
- 25
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Journal of Atherosclerosis and Thrombosis
- Accession number :
- edsair.doi.dedup.....d0da675d5d263171f0310d1d28b18c28