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The influence of pre-radiation salivary flow rates and radiation dose on parotid salivary gland dysfunction in patients receiving radiotherapy for head and neck cancers
- Source :
- Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry. 18(3)
- Publication Year :
- 1998
-
Abstract
- Radiotherapy (RT) used for head and neck cancers causes permanent salivary gland dysfunction (SGD). Previous short-term studies have demonstrated that pre-RT salivary flow rates and the amount of radiation exposure to parotid glands influence the amount of RT-induced SGD. The purpose of this study was to determine which variables are related to the development of long-term post-RT SGD. Parotid flow rates (PFR) were assessed prior to and 1 year after completion of RT in spared parotid glands from 34 patients from 2 parotid-sparing protocols. The results reveal that spared PFR were not significantly higher 1 year post-RT in patients who had high pre-RT PFR, when compared with patients with low pre-RT PFR. However, patients who received higher doses of RT to spared parotid glands had lower PFR 1 year post-RT, compared with patients who had received lower doses of RT. These one-year findings suggest that high pre-RT PFR do not provide protection against RT-induced SGD. Conversely, reduced RT dosages to contralateral parotid glands are protective of PFR after completion of RT.
- Subjects :
- Adult
Male
medicine.medical_specialty
Pathology
Dose
medicine.medical_treatment
Urology
Salivary Gland Diseases
Radiation Dosage
stomatognathic system
medicine
Humans
Parotid Gland
In patient
Head and neck
General Dentistry
Aged
Aged, 80 and over
Salivary gland
business.industry
Radiation dose
Dose-Response Relationship, Radiation
Middle Aged
Radiation exposure
Radiation therapy
medicine.anatomical_structure
Head and Neck Neoplasms
Dental Care for Chronically Ill
Female
Parotid Diseases
Cranial Irradiation
business
Salivation
Secretory Rate
Biomedical sciences
Subjects
Details
- ISSN :
- 02751879
- Volume :
- 18
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry
- Accession number :
- edsair.doi.dedup.....d0cf784137bbeec9632080845f43c62d