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A case report of the effect of plasma exchange on reactive hemophagocytic syndrome associated with toxic shock syndrome
- Source :
- Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy. 8(6)
- Publication Year :
- 2005
-
Abstract
- We report here the case of a patient suffering from hemophagocytic syndrome (HPS) associated with toxic shock syndrome (TSS). A 50-year-old man was admitted because of fever, watery diarrhea and shortness of breath. Clinical analysis revealed systemic cyanosis, sunburn-like erythema and septic shock. Staphylococcus aureus was identified from both blood and sputum culture and the serum enterotoxin A antibody test was positive, suggesting that this was a case of TSS. Though the respiratory and hemodynamic status improved by the mechanical ventilation, fluid resuscitation with catecholamine and antibiotic therapy, the platelet count decreased rapidly. Bone marrow aspiration revealed a large quantity of hemophagocytosis by macrophages. This reactive HPS was treated not with immunosuppressive drugs but with therapeutic plasma exchange in order to prevent worsening of S. aureus infection. After plasma exchange, the circulating macrophage colony-stimulating factor (M-CSF) level was reduced and the platelet count increased rapidly. Bacteria associated HPS remains a difficult diagnosis with high mortality and there is a crucial question of whether this should be treated with immunosuppressive drugs. The patient's clinical course would suggest that the therapeutic plasma exchange should be considered as a therapeutic tool for the bacteria associated HPS instead of immunosuppressive drugs.
- Subjects :
- Male
Resuscitation
Erythema
Histiocytosis, Non-Langerhans-Cell
Sputum culture
medicine
Humans
medicine.diagnostic_test
Plasma Exchange
Septic shock
business.industry
Macrophage Colony-Stimulating Factor
Toxic shock syndrome
Hematology
Middle Aged
medicine.disease
Shock, Septic
Anti-Bacterial Agents
Nephrology
Shock (circulatory)
Immunology
Drug Therapy, Combination
Reactive Hemophagocytic Syndrome
medicine.symptom
Hemophagocytosis
business
Subjects
Details
- ISSN :
- 17449979
- Volume :
- 8
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
- Accession number :
- edsair.doi.dedup.....d0c7e73a0ad29338a3a6aa2b1f5f81c6