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Undetected Chikungunya virus co-infections in a Brazilian region presenting hyper-endemic circulation of Dengue and Zika
- Source :
- Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology. 113
- Publication Year :
- 2018
-
Abstract
- Background Chikungunya virus (CHIKV) causes a disease characterized by acute onset of fever accompanied by arthralgia. Clinical similarities and co-circulation of other arboviruses such as Dengue virus (DENV) and Zika virus (ZIKV), have complicated their differentiation, making their diagnoses a challenge for the health authorities. Misdiagnosis is a serious issue to the management of patients and development of public health measures. Objectives We carried out further screening of CHIKV, DENV and ZIKV cases in Minas Gerais, Brazil, after diagnostics were already issued by a state laboratory and according to the Brazilian Ministry of Health (BMH) policy. Our aim was to look for possible co-infections or previous arboviruses’ exposure. Study design Sera from 193 patients with symptoms of arboviral infections were tested for DEV, ZKV and/or CHIKV by the State laboratory, according to clinical suspicion and following standard BMH guidelines. After an official diagnosis was issued for each patient, we retested samples applying a broader panel of ELISA-based serological tests. Results We identified 13 patients with concurrent or consecutive infections (IgM positive for more than one arbovirus), including 11 individuals that were positive for CHIKV and other previously confirmed arbovirus infection. Discussion Guidelines established in many arbovirus-endemic countries prioritizes the diagnosis of Zika and Dengue and no further analyzes are done when samples are positive for those viruses. As a result, possible cases of co-infections with chikungunya are neglected, which affects the epidemiological assessments of virus circulation, patient management, and the development of public health policies.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Endemic Diseases
viruses
030106 microbiology
Disease
Dengue virus
medicine.disease_cause
Antibodies, Viral
Arbovirus
Zika virus
Dengue fever
Disease Outbreaks
Dengue
03 medical and health sciences
0302 clinical medicine
Pregnancy
Virology
Epidemiology
Medicine
Humans
Serologic Tests
030212 general & internal medicine
Chikungunya
biology
business.industry
Coinfection
Zika Virus Infection
Public health
Infant, Newborn
virus diseases
biology.organism_classification
medicine.disease
Infectious Diseases
Chikungunya Fever
RNA, Viral
Female
business
Brazil
Subjects
Details
- ISSN :
- 18735967
- Volume :
- 113
- Database :
- OpenAIRE
- Journal :
- Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
- Accession number :
- edsair.doi.dedup.....d0b7866c987c47e6dbfa34b0f15a8ac6