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Baloxavir treatment of oseltamivir‐resistant influenza A/H1pdm09 in two immunocompromised patients
- Source :
- Transplant Infectious Disease. 23
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Few treatment options are available for oseltamivir-resistant influenza. It has been proposed that baloxavir can be effective in this setting due to its distinct mechanism of action but clinical experience is lacking for immunocompromised patients. We report two such cases treated with baloxavir after failure of oseltamivir and detection of oseltamivir resistance mutations. Baloxavir/zanamivir combination therapy was effective in one patient, but persistent viral shedding was noted with baloxavir monotherapy in the other patient.
- Subjects :
- Dibenzothiepins
Influenzavirus A
Oseltamivir
Combination therapy
Pyridones
medicine.drug_class
Morpholines
viruses
Neuraminidase
030230 surgery
Antiviral Agents
Immunocompromised Host
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Zanamivir
Drug Resistance, Viral
Influenza, Human
medicine
Humans
Viral shedding
Transplantation
Neuraminidase inhibitor
Triazines
business.industry
virus diseases
Influenza a
biochemical phenomena, metabolism, and nutrition
medicine.disease
Virology
respiratory tract diseases
Lymphoma
Infectious Diseases
Mechanism of action
chemistry
030211 gastroenterology & hepatology
medicine.symptom
business
medicine.drug
Subjects
Details
- ISSN :
- 13993062 and 13982273
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Transplant Infectious Disease
- Accession number :
- edsair.doi.dedup.....d0aafd5e476a7a1db0901b09ce2527a3