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Revascularization Outcomes in Patients With Acute Limb Ischemia and Active Neoplastic Disease
- Source :
- Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists. 28(1)
- Publication Year :
- 2020
-
Abstract
- Purpose To report the outcomes of surgical (ST), endovascular (ET), and hybrid (HT) treatment in cancer patients with acute limb ischemia (ALI). Materials and Methods A multicenter retrospective registry collected 139 patients (mean age 72.3±12.4 years; 73 men) with ALI and active malignancy treated by ET (41, 29%), ST (70, 51%), or HT (28, 20%) in 7 European centers between July 2007 and February 2019. In 22 cases (16%) ALI was the first manifestation of the malignancy. Lung cancer was the most common diagnosis (38, 27%). The primary composite outcome was amputation-free survival (AFS). Overall survival, amputation-free time (AFT), and reintervention-free time (RFT) were also assessed. Cox regression analysis was applied to identify independent risk factors for the primary and secondary outcomes. Results are presented as the hazard ratio (HR) and 95% confidence intervals (CIs). Results ET was associated with improved 12-month AFS compared with both ST (HR 2.27, 95% CI 1.20 to 4.28, p=0.002) and HT (HR 2.14, 95% CI 1.09 to 4.18, p=0.008). ST (HR 2.50, 95% CI 1.19 to 5.53, p=0.003) and HT (HR 3.10, 95% CI 1.45 to 6.65, pConclusion In patients with ALI and active malignant disease, ET was associated with increased AFS and overall survival compared with both ST and HT, while the limb salvage and reintervention rates were comparable among the 3 groups.
- Subjects :
- Male
medicine.medical_specialty
Time Factors
medicine.medical_treatment
Revascularization
Malignancy
Endovascular therapy
Amputation, Surgical
Peripheral Arterial Disease
Ischemia
Risk Factors
Neoplasms
medicine
Humans
Radiology, Nuclear Medicine and imaging
In patient
Aged
Retrospective Studies
Aged, 80 and over
business.industry
Endovascular Procedures
Neoplastic disease
Cancer
Middle Aged
medicine.disease
Limb Salvage
Limb ischemia
Surgery
Treatment Outcome
Amputation
Female
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 15451550
- Volume :
- 28
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists
- Accession number :
- edsair.doi.dedup.....d09a44b50f74d50d74c44d5db711d369