Diabetes and hepatocellular cancer risk: Not only a matter of hyperglycemia

The obesity and diabetes epidemics are driving the NAFLD epidemic. Although the overall risk of HCC in NAFLD is lower than in liver disease of different etiology, the very high number of cases will constitute a worldwide challenge for National Health Systems. The diabetes-associated progression of NASH/cryptogenic cirrhosis to HCC is slow, but effective treatments are limited by comorbidities, which also reduce the inclusion in liver transplant lists. New diabetes treatments might help decrease the future burden of diabetes-associated HCC.