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Rhinocerebral mucormycosis following donor leukocyte infusion: successful treatment with liposomal amphotericin B and surgical debridement
- Source :
- Bone marrow transplantation. 22(8)
- Publication Year :
- 1998
-
Abstract
- A 24-year-old male developed cytogenetic relapse of chronic myeloid leukemia (CML) four years after allogeneic BMT. After a year of treatment with IFN-alpha, he achieved a partial cytogenetic response. Treatment with donor leukocyte infusions (DLI) was given (total dose 1 x 10(8) T lymphocytes/kg). Two months later, he developed acute GVHD (skin and liver), that improved with CsA and methylprednisolone and resulted in cytogenetic remission with complete donor chimerism. One month later he developed rhinocerebral mucormycosis and was successfully treated with surgical debridement and liposomal amphotericin B (total dose 12 g). This is the first case of mucormycosis described after DLI.
- Subjects :
- Adult
Male
medicine.medical_specialty
Antifungal Agents
medicine.medical_treatment
Blood product
Amphotericin B
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
medicine
Humans
Mucormycosis
Transplantation, Homologous
Mycosis
Transplantation
Chemotherapy
Brain Diseases
Drug Carriers
business.industry
Myeloid leukemia
Hematology
medicine.disease
Surgery
Leukocyte Transfusion
Methylprednisolone
Liposomes
Complication
business
medicine.drug
Subjects
Details
- ISSN :
- 02683369
- Volume :
- 22
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Bone marrow transplantation
- Accession number :
- edsair.doi.dedup.....d07db5ba20fa237ccff0e71a3b93fa8f