Satietin: A highly potent anorexogenic substance in human serum

A substance named satietin, capable of reducing food intake drastically in rats deprived of food for 96 hr, was discovered in human serum. The substance was extracted and purified by gelchromatographic techniques. The purified satietin containing samples exerted a dose-dependent anorexogenic effect both at intravenous and intracerebroventricular injection. The C-terminal octapeptide of cholecystokinin (CCK-OP) and pGlu-His-GlyOH, the peptides described to reduce food intake in nonstarving rodents, were found to be devoid of satietin-like effect in rats deprived of food for 4 days.