Back to Search
Start Over
Pharmacokinetic/pharmacodynamic profile of reslizumab in asthma
- Source :
- Expert Opinion on Drug Metabolism & Toxicology. 14:239-245
- Publication Year :
- 2017
- Publisher :
- Informa UK Limited, 2017.
-
Abstract
- Introduction: Allergic asthma is a Th2-driven inflammatory process characterized by the infiltration of eosinophils into the airways. IL-5 is a key trigger for eosinophil expansion and release from the bone marrow and plays a crucial role in the entire life span of eosinophils from differentiation to maturation and survival. IL-5 can be considered among the most obvious targets to selectively inhibit eosinophilic airway inflammation. Areas covered: The preclinical and clinical development of reslizumab, a humanized mAb against IL-5 that has been developed to block IL-5 bioactivity and reduce biologically available IL-5, are described with a particular focus on its pharmacodynamics (PK)/pharmacokinetic (PD) profile. Expert opinion: Although pivotal trials have documented that reslizumab can be recommended as add-on therapy for the treatment of patients with severe eosinophilic asthma, there is still important information that is lacking and some PK and PD properties of reslizumab are still not fully understood.
- Subjects :
- Settore MED/10 - Malattie dell'Apparato Respiratorio
Asthma
eosinophils
humanized monoclonal antibody
interleukin-5
reslizumab
Eosinophil
Antibodies, Monoclonal, Humanized
Toxicology
Severity of Illness Index
03 medical and health sciences
Th2 Cells
0302 clinical medicine
Reslizumab
medicine
Animals
Humans
Anti-Asthmatic Agent
Anti-Asthmatic Agents
030212 general & internal medicine
Th2 Cell
Interleukin 5
Inflammation
Pharmacology
Animal
business.industry
Pharmacokinetic pharmacodynamic
Allergic asthma
General Medicine
respiratory system
medicine.disease
respiratory tract diseases
medicine.anatomical_structure
030228 respiratory system
Immunology
business
Infiltration (medical)
Human
medicine.drug
Subjects
Details
- ISSN :
- 17447607 and 17425255
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Expert Opinion on Drug Metabolism & Toxicology
- Accession number :
- edsair.doi.dedup.....d0730d03cc25578aa7a7020d31dca8a2