Back to Search
Start Over
Reduced Rate of Neural Differentiation in the Dentate Gyrus of Adult Dysbindin Null (Sandy) Mouse
- Source :
- PLoS ONE, Vol 6, Iss 1, p e15886 (2011), PLoS ONE
- Publication Year :
- 2011
- Publisher :
- Public Library of Science (PLoS), 2011.
-
Abstract
- Genetic variations in the gene encoding dysbindin has consistently been associated with schizophrenia and bipolar disorder, although little is known about the neural functions carried out by dysbindin. To gain some insight into this area, we took advantage of the readily available dysbindin-null mouse sandy (sdy-/-) and studied hippocampal neurogenesis using thymidine analogue bromodeoxuridine (BrdU). No significant differences were found in the proliferation (4 hours) or survival (1, 4 and 8 weeks after the last BrdU injection) of progenitors in the subgranular regions of the dentate gyrus between sdy-/- and sdy+/+ (control) mice. However, 4 weeks after the last BrdU injection, a significant reduction was observed in the ratio of neuronal differentiation in sdy-/- when compared to that of sdy+/+ (sdy+/+ = 87.0 ± 5.3% vs. sdy-/- = 71.3 ± 8.3%, p = 0.01). These findings suggest that dysbindin plays a role during differentiation process in the adult hippocampal neurogenesis and that its deficit may negatively affect neurogenesis-related functions such as cognition and mood.
- Subjects :
- medicine.medical_specialty
Time Factors
Cell Survival
Neurogenesis
Cellular differentiation
lcsh:Medicine
Hippocampus
Hippocampal formation
Mice
Internal medicine
Molecular Cell Biology
medicine
Animals
Progenitor cell
lcsh:Science
Psychiatry
Biology
Cell Proliferation
Neurons
Multidisciplinary
Dentate gyrus
Dysbindin
lcsh:R
Cell Differentiation
medicine.disease
Mice, Mutant Strains
Mental Health
Endocrinology
Neurology
Schizophrenia
Dentate Gyrus
Dystrophin-Associated Proteins
Medicine
lcsh:Q
Carrier Proteins
Research Article
Neuroscience
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....d070ee3ac461ca600f101770fe1ef1e0