Back to Search
Start Over
Supraclavicular recurrence after early breast cancer: a curable condition?
- Source :
- Pedersen, A N, Møller, S, Steffensen, K D, Haahr, V, Jensen, M, Kempel, M M, Jepsen, S L, Madsen, E L, Roslind, A, Sandberg, E, Schöllkopf, C, Sørensen, P G, Windfeldt, K M & Andersson, M 2010, ' Supraclavicular recurrence after early breast cancer: a curable condition? ', Breast Cancer Research and Treatment, vol. 125, no. 7, pp. 815-822 . https://doi.org/10.1007/s10549-010-0918-8, Breast Cancer Research and Treatment, Breast Cancer Research and Treatment, Springer Verlag, 2010, 125 (3), pp.815-822. ⟨10.1007/s10549-010-0918-8⟩
- Publication Year :
- 2010
- Publisher :
- Springer Science and Business Media LLC, 2010.
-
Abstract
- Udgivelsesdato: 2010-May-8 The prognosis of ipsilateral supraclavicular lymph node recurrence after early breast cancer appears to be worse than for other loco-regional recurrences, but better than for distant metastases. The purpose of the present study was to investigate the relationship between different types of salvage treatment and primary patient characteristics, treatment response, and survival after supraclavicular recurrence (SR) in a large patient population. From the Danish Breast Cancer Cooperative Group treatment database 1977-2003, 305 patients were identified with SR without distant disease as site of first recurrence. Salvage treatment types as well as other factors were related to response and survival. The median follow-up time for progression after SR was 25 months. Complete remission was 76% among patients receiving excision surgery, 67% with combined loco-regional and systemic therapy, and 48% with systemic therapy alone. Median progression-free survival (PFS) and overall survival was 18 and 29 months, respectively. The 5-year PFS probability was 15%. In univariate analysis, combination salvage therapy, negative nodal status and low malignancy grade were related to longer PFS. In multivariate analysis, salvage therapy and malignancy grade remained independent factors for survival. In conclusion, the prognosis of SR is generally poor. However, it appears to be a curable condition. An independent marker of improved outcome is local and systemic combination salvage treatment, which can be considered.
- Subjects :
- Adult
Oncology
Cancer Research
medicine.medical_specialty
Denmark
Salvage therapy
Breast Neoplasms
Disease-Free Survival
030218 nuclear medicine & medical imaging
Cohort Studies
03 medical and health sciences
Breast cancer
0302 clinical medicine
Recurrence
Internal medicine
medicine
Humans
Aged
Proportional Hazards Models
Retrospective Studies
Supraclavicular
Univariate analysis
Proportional hazards model
business.industry
Remission Induction
Cancer
Retrospective cohort study
Middle Aged
Prognosis
medicine.disease
3. Good health
Supraclavicular lymph nodes
Surgery
Treatment Outcome
medicine.anatomical_structure
030220 oncology & carcinogenesis
Multivariate Analysis
Disease Progression
Therapy
Breast disease
Neoplasm Recurrence, Local
business
Subjects
Details
- ISSN :
- 15737217 and 01676806
- Volume :
- 125
- Database :
- OpenAIRE
- Journal :
- Breast Cancer Research and Treatment
- Accession number :
- edsair.doi.dedup.....d05c6359e43ffbcc69b1b872993abc7f