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The 115 Year Old Multicomponent Bargellini Reaction: Perspectives and New Applications
- Source :
- Molecules, Vol 26, Iss 558, p 558 (2021), Molecules
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Despite its uniqueness, the Bargellini multicomponent reaction remains barely known by the most part of chemists. This can be ascribed to the fact that this transformation has not been adequately reviewed in the classic books of named reactions in organic chemistry. Nevertheless, several works on this reaction have been carried out over the years, many of them were written in Italian in the period 1929–1966. In this review article we extensively cover, in a chronological order, the most important applications of the Bargellini reaction reported to date, with the hope that this knowledge-sharing will help chemists to properly use this multicomponent transformation and imagine novel reactivities based on it.
- Subjects :
- Engineering
multicomponent reaction
chlorobutanol
business.industry
chloroform
Organic Chemistry
Bargellini reaction
Chemistry, Organic
Pharmaceutical Science
Review
History, 20th Century
α-aryl isobutyric acids
Analytical Chemistry
Epistemology
lcsh:QD241-441
Italy
lcsh:Organic chemistry
Chemistry (miscellaneous)
Drug Discovery
Molecular Medicine
Physical and Theoretical Chemistry
business
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 26
- Issue :
- 558
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....d04c383852e511abdfae510cacbb87e6