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Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells
- Source :
- Cell. 182(3)
- Publication Year :
- 2019
-
Abstract
- Piloerection (goosebumps) requires concerted actions of the hair follicle, the arrector pili muscle (APM), and the sympathetic nerve, providing a model to study interactions across epithelium, mesenchyme, and nerves. Here, we show that APMs and sympathetic nerves form a dual-component niche to modulate hair follicle stem cell (HFSC) activity. Sympathetic nerves form synapse-like structures with HFSCs and regulate HFSCs through norepinephrine, whereas APMs maintain sympathetic innervation to HFSCs. Without norepinephrine signaling, HFSCs enter deep quiescence by down-regulating the cell cycle and metabolism while up-regulating quiescence regulators Foxp1 and Fgf18. During development, HFSC progeny secretes Sonic Hedgehog (SHH) to direct the formation of this APM-sympathetic nerve niche, which in turn controls hair follicle regeneration in adults. Our results reveal a reciprocal interdependence between a regenerative tissue and its niche at different stages and demonstrate sympathetic nerves can modulate stem cells through synapse-like connections and neurotransmitters to couple tissue production with demands.
- Subjects :
- Male
Cell type
Sympathetic Nervous System
Mesenchyme
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
Mice
Norepinephrine
0302 clinical medicine
Accessory Nerve
medicine
Animals
Humans
Hedgehog Proteins
RNA-Seq
Sonic hedgehog
Stem Cell Niche
030304 developmental biology
0303 health sciences
biology
Regeneration (biology)
Gene Expression Profiling
Stem Cells
Arrector pili muscle
Cell Cycle
Forkhead Transcription Factors
Hair follicle
Smoothened Receptor
Epithelium
Cell biology
Piloerection
Cold Temperature
Fibroblast Growth Factors
Mice, Inbred C57BL
Repressor Proteins
medicine.anatomical_structure
Synapses
biology.protein
Female
Receptors, Adrenergic, beta-2
Stem cell
Hair Follicle
030217 neurology & neurosurgery
Hair
Signal Transduction
Subjects
Details
- ISSN :
- 10974172
- Volume :
- 182
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Cell
- Accession number :
- edsair.doi.dedup.....d0438cf284cd9017a6c8bab43f9ed392