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Creatine in the central nervous system
- Source :
- Rackayova, V, Cudalbu, C, Pouwels, P J W & Braissant, O 2017, ' Creatine in the central nervous system : From magnetic resonance spectroscopy to creatine deficiencies ', Analytical Biochemistry, vol. 529, pp. 144-157 . https://doi.org/10.1016/j.ab.2016.11.007
- Publication Year :
- 2017
-
Abstract
- Creatine (Cr) is an important organic compound acting as intracellular high-energy phosphate shuttle and in energy storage. While located in most cells where it plays its main roles in energy metabolism and cytoprotection, Cr is highly concentrated in muscle and brain tissues, in which Cr also appears to act in osmoregulation and neurotransmission. This review discusses the basis of Cr metabolism, synthesis and transport within brain cells. The importance of Cr in brain function and the consequences of its impaired metabolism in primary and secondary Cr deficiencies are also discussed. Cr and phosphocreatine (PCr) in living systems can be well characterized using in vivo magnetic resonance spectroscopy (MRS). This review describes how (1)H MRS allows the measurement of Cr and PCr, and how (31)P MRS makes it possible to estimate the creatine kinase (CK) rate constant and so detect dynamic changes in the Cr/PCr/CK system. Absolute quantification by MRS using creatine as internal reference is also discussed. The use of in vivo MRS to study brain Cr in a non-invasive way is presented, as well as its use in clinical and preclinical studies, including diagnosis and treatment follow-up in patients.
- Subjects :
- 0301 basic medicine
Magnetic Resonance Spectroscopy
Central nervous system
Biophysics
Creatine
Biochemistry
Models, Biological
Phosphocreatine
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
medicine
Animals
Humans
Molecular Biology
CIBM-AIT
Brain Diseases
biology
Brain
Cell Biology
Metabolism
Cytoprotection
Magnetic Resonance Imaging
Guanidinoacetate N-methyltransferase
030104 developmental biology
medicine.anatomical_structure
chemistry
biology.protein
Creatine kinase
Energy Metabolism
030217 neurology & neurosurgery
Intracellular
Subjects
Details
- Language :
- English
- ISSN :
- 00032697
- Volume :
- 529
- Database :
- OpenAIRE
- Journal :
- Analytical Biochemistry
- Accession number :
- edsair.doi.dedup.....d039e7d15ad63e9603727ba344afae30