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Predictors of pregnancy complications in women with congenital heart disease
- Source :
- European Heart Journal, 31, 2124-32, European heart journal, 31(17), 2124-2132. Oxford University Press, European Heart Journal, 31, 17, pp. 2124-32, European Heart Journal, 31(17), 2124-2132, European Heart Journal, 31(17), 2124-2132. Oxford University Press
- Publication Year :
- 2010
-
Abstract
- Contains fulltext : 89656.pdf (Publisher’s version ) (Closed access) AIMS: Data regarding pregnancy outcome in women with congenital heart disease (CHD) are limited. METHODS AND RESULTS: In 1802 women with CHD, 1302 completed pregnancies were observed. Independent predictors of cardiac, obstetric, and neonatal complications were calculated using logistic regression. The most prevalent cardiac complications during pregnancy were arrhythmias (4.7%) and heart failure (1.6%). Factors independently associated with maternal cardiac complications were the presence of cyanotic heart disease (corrected/uncorrected) (P < 0.0001), the use of cardiac medication before pregnancy (P < 0.0001), and left heart obstruction (P < 0.0001). New characteristics were mechanical valve replacement (P = 0.0014), and systemic (P = 0.04) or pulmonary atrioventricular valve regurgitation related with the underlying (moderately) complex CHD (P = 0.03). A new risk score for cardiac complications is proposed. The most prevalent obstetric complications were hypertensive complications (12.2%). No correlation of maternal characteristics with adverse obstetric outcome was found. The most prevalent neonatal complications were premature birth (12%), small for gestational age (14%), and mortality (4%). Cyanotic heart disease (corrected/uncorrected) (P = 0.0003), mechanical valve replacement (P = 0.03), maternal smoking (P = 0.007), multiple gestation (P = 0.0014), and the use of cardiac medication (P = 0.0009) correlated with adverse neonatal outcome. CONCLUSION: In our tertiary CHD cohort, cardiac, obstetric, and neonatal complications were frequently encountered, and (new) correlations of maternal baseline data with adverse outcome are reported. A new risk score for adverse cardiac complications is proposed, although prospective validation remains necessary. 01 september 2010
- Subjects :
- Adult
Heart Defects, Congenital
medicine.medical_specialty
Complications
Heart disease
Pregnancy Complications, Cardiovascular
Congenital heart disease Pregnancy Complications cardiac complications biventricular repair aortic-stenosis task-force outcomes risk recurrence management fertility delivery
Risk Assessment
BIVENTRICULAR REPAIR
DELIVERY
Young Adult
Pregnancy
Risk Factors
Internal medicine
MANAGEMENT
FERTILITY
Medicine
Humans
RECURRENCE
AORTIC-STENOSIS
Congenital heart disease
Retrospective Studies
CARDIAC COMPLICATIONS
RISK
Heart Failure
OUTCOMES
Framingham Risk Score
Cardiovascular diseases [NCEBP 14]
business.industry
Pregnancy Outcome
Retrospective cohort study
Arrhythmias, Cardiac
Middle Aged
medicine.disease
Premature birth
Heart failure
Cardiovascular agent
Cardiology
Small for gestational age
Female
Cardiology and Cardiovascular Medicine
business
TASK-FORCE
Maternal Age
Subjects
Details
- ISSN :
- 0195668X
- Database :
- OpenAIRE
- Journal :
- European Heart Journal, 31, 2124-32, European heart journal, 31(17), 2124-2132. Oxford University Press, European Heart Journal, 31, 17, pp. 2124-32, European Heart Journal, 31(17), 2124-2132, European Heart Journal, 31(17), 2124-2132. Oxford University Press
- Accession number :
- edsair.doi.dedup.....d0347afd794a849a137bbdcc7fe73269