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Cardiac Outcomes in Adults With Mitochondrial Diseases
- Source :
- Journal of the American College of Cardiology, Journal of the American College of Cardiology, 2022, 80 (15), pp.1421-1430. ⟨10.1016/j.jacc.2022.08.716⟩
- Publication Year :
- 2022
- Publisher :
- HAL CCSD, 2022.
-
Abstract
- International audience; Background: Patients with mitochondrial diseases are at risk of heart failure (HF) and arrhythmic major adverse cardiac events (MACE). Objectives: We developed prediction models to estimate the risk of HF and arrhythmic MACE in this population. Methods: We determined the incidence and searched for predictors of HF and arrhythmic MACE using Cox regression in 600 adult patients from a multicenter registry with genetically confirmed mitochondrial diseases. Results: Over a median follow-up time of 6.67 years, 29 patients (4.9%) reached the HF endpoint, including 19 hospitalizations for nonterminal HF, 2 cardiac transplantations, and 8 deaths from HF. Thirty others (5.1%) reached the arrhythmic MACE, including 21 with third-degree or type II second-degree atrioventricular blocks, 4 with sinus node dysfunction, and 5 sudden cardiac deaths. Predictors of HF were the m.3243A>G variant (HR: 4.3; 95% CI: 1.8-10.1), conduction defects (HR: 3.0; 95% CI: 1.3-6.9), left ventricular (LV) hypertrophy (HR: 2.6; 95% CI: 1.1-5.8), LV ejection fraction
- Subjects :
- Adult
conduction disease
mitochondrial diseases
[SDV]Life Sciences [q-bio]
heart failure
sudden death
Heart
Stroke Volume
Prognosis
DNA, Mitochondrial
Ventricular Function, Left
single large-scale deletions
Risk Factors
Humans
Hypertrophy, Left Ventricular
Cardiology and Cardiovascular Medicine
m3243A>G
Subjects
Details
- Language :
- English
- ISSN :
- 07351097 and 15583597
- Database :
- OpenAIRE
- Journal :
- Journal of the American College of Cardiology, Journal of the American College of Cardiology, 2022, 80 (15), pp.1421-1430. ⟨10.1016/j.jacc.2022.08.716⟩
- Accession number :
- edsair.doi.dedup.....d02e3babcfab5edc418372f23ceac8a2