Back to Search
Start Over
New Insights into the Mechanisms of Pyroptosis and Implications for Diabetic Kidney Disease
- Source :
- International Journal of Molecular Sciences, Vol 21, Iss 7057, p 7057 (2020), International Journal of Molecular Sciences
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- Pyroptosis is one special type of lytic programmed cell death, featured in cell swelling, rupture, secretion of cell contents and remarkable proinflammation effect. In the process of pyroptosis, danger signalling and cellular events are detected by inflammasome, activating caspases and cleaving Gasdermin D (GSDMD), along with the secretion of IL-18 and IL-1β. Pyroptosis can be divided into canonical pathway and non-canonical pathway, and NLRP3 inflammasome is the most important initiator. Diabetic kidney disease (DKD) is one of the most serious microvascular complications in diabetes. Current evidence reported the stimulatory role of hyperglycaemia-induced cellular stress in renal cell pyroptosis, and different signalling pathways have been shown to regulate pyroptosis initiation. Additionally, the inflammation and cellular injury caused by pyroptosis are tightly implicated in DKD progression, aggravating renal fibrosis, glomerular sclerosis and tubular injury. Some registered hypoglycaemia agents exert suppressive activity in pyroptosis regulation pathway. Latest studies also reported some potential approaches to target the pyroptosis pathway, which effectively inhibits renal cell pyroptosis and alleviates DKD in in vivo or in vitro models. Therefore, comprehensively compiling the information associated with pyroptosis regulation in DKD is the main aim of this review, and we try to provide new insights for researchers to dig out more potential therapies of DKD.
- Subjects :
- 0301 basic medicine
Programmed cell death
Inflammasomes
kidney disease
Cell
Inflammation
Review
Kidney
Catalysis
lcsh:Chemistry
Inorganic Chemistry
03 medical and health sciences
0302 clinical medicine
cellular stress
diabetic
medicine
Renal fibrosis
Animals
Humans
Diabetic Nephropathies
Secretion
Physical and Theoretical Chemistry
lcsh:QH301-705.5
Molecular Biology
Spectroscopy
Caspase
biology
business.industry
pyroptosis
fibrosis
Organic Chemistry
Pyroptosis
Inflammasome
General Medicine
Computer Science Applications
030104 developmental biology
medicine.anatomical_structure
lcsh:Biology (General)
lcsh:QD1-999
Caspases
030220 oncology & carcinogenesis
Cancer research
biology.protein
medicine.symptom
business
medicine.drug
Subjects
Details
- ISSN :
- 14220067
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....d027e9d20fe32d7563c751addab18516