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Absorptive clearance of DTPA as an aerosol-based biomarker in the cystic fibrosis airway
- Source :
- European Respiratory Journal. 35:781-786
- Publication Year :
- 2009
- Publisher :
- European Respiratory Society (ERS), 2009.
-
Abstract
- Biomarkers providing in vivo quantification of the basic elements of cystic fibrosis (CF) lung disease are needed. A study was performed to determine whether the absorption of a small radiolabelled hydrophilic molecule (Indium-111 (In-)DTPA) would be increased in CF airways. DTPA clearance has been used previously to assess epithelial permeability and may also be useful for quantifying liquid absorption. The absorptive clearance rate of DTPA was quantified in 10 CF and 11 control subjects using a novel aerosol technique. Subjects inhaled an aerosol containing nonabsorbable technetium-99m sulfur colloid (Tc-SC) particles and In-DTPA. Tc-SC clearance from the lung is exclusively mucociliary, while In-DTPA is cleared by both absorption and mucociliary clearance. The difference between the In-DTPA and Tc-SC clearance rates estimates In-DTPA absorption. Tc-SC (mucociliary) clearance was similar in central and peripheral zones in CF and non-CF lungs. Total In-DTPA clearance was increased in both zones in CF lungs. The absorptive component of In-DTPA clearance was increased in the airway-dominated central lung zones in CF (42% x h( -1) versus 32% x h(-1), p = 0.03). The absorption of In-DTPA is increased in the CF airway. Further study is needed to understand the relative roles of fluid absorption, inflammation and other mechanisms potentially affecting epithelial permeability and DTPA absorption.
- Subjects :
- Adult
Male
Pulmonary and Respiratory Medicine
Pathology
medicine.medical_specialty
Adolescent
Cystic Fibrosis
Mucociliary clearance
animal diseases
Pilot Projects
Respiratory Mucosa
Absorption (skin)
Cystic fibrosis
Article
Young Adult
In vivo
medicine
Humans
Radionuclide Imaging
Aerosols
Lung
business.industry
organic chemicals
Indium Radioisotopes
Respiratory disease
Pentetic Acid
respiratory system
medicine.disease
Respiratory Function Tests
medicine.anatomical_structure
Linear Models
cardiovascular system
Female
business
Clearance rate
Biomarkers
Zones of the lung
circulatory and respiratory physiology
Subjects
Details
- ISSN :
- 13993003 and 09031936
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- European Respiratory Journal
- Accession number :
- edsair.doi.dedup.....d02428406f1cac87414f51dfe5a59167