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Cannabinoid Receptors Overexpression in a Rat Model of Irritable Bowel Syndrome (IBS) after Treatment with a Ketogenic Diet
- Source :
- International Journal of Molecular Sciences, Volume 22, Issue 6, International Journal of Molecular Sciences, Vol 22, Iss 2880, p 2880 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- The administration of a ketogenic diet (KD) has been considered therapeutic in subjects with irritable bowel syndrome (IBS). This study aimed to investigate the molecular mechanisms by which a low-carbohydrate diet, such as KD, can improve gastrointestinal symptoms and functions in an animal model of IBS by evaluating possible changes in intestinal tissue expression of endocannabinoid receptors. In rats fed a KD, we detected a significant restoration of cell damage to the intestinal crypt base, a histological feature of IBS condition, and upregulation of CB1 and CB2 receptors. The diet also affected glucose metabolism and intestinal membrane permeability, with an overexpression of the glucose transporter GLUT1 and tight junction proteins in treated rats. The present data suggest that CB receptors represent one of the molecular pathways through which the KD works and support possible cannabinoid-mediated protection at the intestinal level in the IBS rats after dietary treatment.
- Subjects :
- 0301 basic medicine
Cannabinoid receptor
medicine.medical_treatment
Receptor, Cannabinoid, CB2
lcsh:Chemistry
0302 clinical medicine
Receptor, Cannabinoid, CB1
Cannabinoid receptor type 2
Intestinal Mucosa
Receptors, Cannabinoid
Receptor
lcsh:QH301-705.5
Spectroscopy
Irritable bowel syndrome
biology
General Medicine
Endocannabinoid system
Computer Science Applications
ketogenic diet
Diet, Ketogenic
medicine.medical_specialty
Article
Catalysis
Inorganic Chemistry
03 medical and health sciences
cannabinoid receptors
Internal medicine
medicine
Animals
Humans
Physical and Theoretical Chemistry
Molecular Biology
irritable bowel syndrome
Cannabinoids
business.industry
rat model
Organic Chemistry
Glucose transporter
medicine.disease
Rats
Disease Models, Animal
030104 developmental biology
Endocrinology
lcsh:Biology (General)
lcsh:QD1-999
biology.protein
GLUT1
business
030217 neurology & neurosurgery
Endocannabinoids
Ketogenic diet
Subjects
Details
- ISSN :
- 14220067
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....d0193502e7257bf5e9c64b133948a411